慢性阻塞性肺疾病患者继发肺部真菌感染危险因素分析

发布时间：2018-03-03 00:17

  本文选题：慢性阻塞性肺疾病　切入点：真菌感染　出处：《中华医院感染学杂志》2014年17期 　论文类型：期刊论文

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)患者急性加重期继发肺部真菌感染菌群分布及相关危险因素,为感染预防提供参考依据。方法对2011年1月-2013年3月收治的314例COPD急性加重期患者继发肺部真菌感染进行回顾性分析,分析患者的菌群分布及感染危险因素。结果 314例患者发生肺部真菌感染76例,感染率为24.2%;检出白色假丝酵母菌46株占60.5%、光滑假丝酵母菌8株占10.5%、热带假丝酵母菌8株占10.5%、酵母样真菌6株占7.9%、克柔假丝酵母菌3株占3.9%、曲霉菌属5株占6.6%;经单因素logistic回归分析合并糖尿病、机械通气、血清白蛋白35g/L,Ⅱ型呼吸衰竭、长期使用糖皮质激素、长期应用广谱抗菌药物6个变量与继发真菌感染相关(P0.05);经多因素logistic回归分析,合并糖尿病、机械通气、长期使用糖皮质激素、长期应用广谱抗菌药物是COPD急性加重期继发肺部真菌感染的独立危险因素(P0.05)。结论 COPD急性加重期肺部真菌感染发病率较高,应采取预防控制措施,以降低感染率。
[Abstract]:Objective to investigate the distribution and risk factors of secondary pulmonary fungal infection in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbation. Methods from January 2011 to March 2013, 314 cases of pulmonary fungal infection secondary to acute exacerbation of COPD were retrospectively analyzed. The distribution of bacteria and the risk factors of infection were analyzed. Results there were 76 cases of pulmonary fungal infection in 314 cases. The infection rate was 24.2%, 46 strains of Candida albicans accounted for 60.5%, 8 strains of Candida smooth cells accounted for 10.5%, 8 strains of Candida tropicalis strains accounted for 10.5%, 6 strains of yeast-like fungi accounted for 7.9%, 3 strains of Candida cerevisiae accounted for 3.9 strains, and 5 strains of Aspergillus accounted for 6.6B. Factor logistic regression analysis with diabetes mellitus, Mechanical ventilation, serum albumin 35g / L, type 鈪，

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