致细菌性肝脓肿的肺炎克雷伯杆菌多位点序列分型及临床分析

发布时间：2018-03-03 20:02

本文选题：细菌性肝脓肿　切入点：肺炎克雷伯杆菌　出处：《浙江大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：了解我科收治的致细菌性肝脓肿的肺炎克雷伯杆菌多位点序列分型及临床分析方法：收集2008.3-2012.6在我科住院的细菌性肝脓肿病人,脓液培养为肺炎克雷伯杆菌的46株菌株,对这46株菌株进行多位点序列分型,收集这46个患者的临床资料及药敏结果。结果： 46株菌株经过多位点序列分型：ST23为最主要序列型,包括24株,ST65有4株,ST86有3株,ST29和ST375有2株,ST25、ST30、ST163、ST367、ST374、 ST380、ST660、ST700及ST806各1株,2株为新的ST型,未发现文献报道的产耐碳氢酶烯酶的常见ST型。 46株菌株的药敏结果45株为ESBL-;1株为ESBL+,但对青霉素(三代头孢)复合制剂敏感。结论：我科收治的致细菌性肝脓肿的肺炎克雷伯杆菌均为敏感菌株,可以经验性的选用青霉素(三代头孢)复合制剂,避免碳氢酶烯类抗生素的乱用及滥用。
[Abstract]:Objective:. To understand the multilocus sequence typing and clinical analysis of Klebsiella pneumoniae in patients with bacterial liver abscess treated in our department. Methods:. 46 strains of Klebsiella pneumoniae were collected from bacterial liver abscess patients hospitalized in our department from 2008.3-2012.6. The 46 strains were classified into multiple loci, and the clinical data and drug sensitivity results of 46 strains were collected. Results:. 46 strains were classified by multilocus sequence as the most important sequence types, including 24 strains of ST65, 4 strains of ST86, 3 strains of ST29 and 2 strains of ST375, 2 strains of ST25, 1 strain of ST660T700 and 1 strain of ST806, respectively, which were new ST-type. The drug sensitivity of 46 strains was ESBL-1 ESBL, but sensitive to penicillin (third generation cephalosporin) compound preparation. Conclusion:. Klebsiella pneumoniae which caused bacterial liver abscess in our department are all sensitive strains. We can use penicillin (third generation cephalosporin) compound preparation empirically to avoid the misuse and misuse of hydrocarbons antibiotics.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.1

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