社区获得性肺炎患者血清MMP-9水平的变化与意义

发布时间：2018-03-04 20:19

本文选题：社区获得性肺炎　切入点：基质金属蛋白酶-　出处：《中国卫生检验杂志》2014年19期 　论文类型：期刊论文

【摘要】：目的探讨基质金属蛋白酶-9(MMP-9)在社区获得性肺炎(CAP)患者血清中的水平变化及其诊断价值。方法100例成人CAP患者为病例组,96例成人健康体检者为对照组,采用ELISA法检测病例组发病期、治疗后与对照组血清MMP-9的水平,以受试者工作特征(ROC)曲线分析血清MMP-9水平在CAP中的诊断价值;并对病例组血清MMP-9水平与白细胞计数(WBC)、中性粒细胞比例(NEUT)进行相关性分析。结果病例组发病期MMP-9水平明显高于治疗后与对照组(P0.001),治疗后MMP-9水平与对照组差异无统计学意义(P=0.120)。MMP-9的ROC曲线下面积为0.749,Cutoff值为231.05 ng/ml时,灵敏度和特异度分别为0.641、0.780,阳性预测值和阴性预测值分别为0.743、0.684。病例组血清MMP-9水平与WBC、NEUT均呈正相关(r分别为0.503、0.307,P0.001、P0.013)。结论 MMP-9参与了CAP的炎症反应过程,并可作为诊断CAP的一种血清标志物。
[Abstract]:Objective to investigate the serum level of matrix metalloproteinase-9 (MMP-9) in patients with community-acquired pneumonia (CPAP) and its diagnostic value. ELISA method was used to detect the level of serum MMP-9 after treatment and control group. The diagnostic value of serum MMP-9 level in CAP was analyzed by the operating characteristics of the subjects. The correlation between serum MMP-9 level and WBC count and neutrophil ratio was analyzed. Results the level of MMP-9 in the case group was significantly higher than that in the control group after treatment (P 0.001). There was no significant difference between the MMP-9 level after treatment and that in the control group. When the area under the ROC curve is 0.749 ng/ml, the cutoff value of MMP-9 is 231.05 ng/ml. The sensitivity and specificity were 0.641 ~ 0.780, positive predictive value and negative predictive value were 0.743n 0.684 respectively. There was a positive correlation between the serum MMP-9 level and WBCfNEUT in the case group. The positive correlation between MMP-9 and WBCfNEUT was 0.5030.307P0.001P0.0130.Conclusion MMP-9 is involved in the inflammatory reaction of CAP, and the positive predictive value and negative predictive value are 0.743nb and 0.684.Conclusion MMP-9 is involved in the inflammatory reaction of CAP. It can be used as a serum marker for the diagnosis of CAP.
【作者单位】：中山大学附属第三医院急诊科;中山大学附属第三医院重症医学科;
【基金】：广东省科技计划项目(2011B031800075)
【分类号】：R563.1

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