CT定量分析观察慢性阻塞性肺疾病患者的肺小血管改变

发布时间：2018-03-05 13:48

本文选题：肺疾病　切入点：慢性阻塞性　出处：《中国医学影像技术》2015年02期 　论文类型：期刊论文

【摘要】：目的探索CT定量分析手段对慢性阻塞性肺疾病(COPD)小血管变化的识别能力,分析COPD患者肺小血管变化的影响因素。方法回顾性收集121例COPD患者,其中48例患者有2次扫描结果,间隔时间超过1年。肺气肿定量以-950HU密度以下低衰减区体积占总肺体积的百分比(%LAA-950)表示,单位面积内肺小血管的数量反应肺小血管的改变。分析各级二维平面内血管数量与%LAA-950的相关性。结果右肺上叶尖段路径第5级支气管与全肺%LAA-950呈明显负相关(r=-0.87,P0.01)。对比48例COPD患者的2次扫描结果,发现吸烟者(P=0.02)较既往吸烟者(P=0.07)单位面积内血管数量减少更明显。结论 CT定量分析COPD患者肺小血管数量的改变,具有直观、可量化的优点。COPD患者肺小血管的改变受吸烟状态和肺气肿的影响。
[Abstract]:Objective to explore the ability of CT quantitative analysis to recognize the changes of small blood vessels in patients with chronic obstructive pulmonary disease (COPD), and to analyze the influencing factors of the changes of small blood vessels in patients with COPD. Methods 121 patients with COPD were collected retrospectively, 48 of whom had two scans. The interval is more than one year. Emphysema is quantitatively expressed as a percentage of the volume of the low attenuation area below -950HU density as a percentage of the total lung volume (LAA-950), The number of small pulmonary vessels in unit area reflects the changes of pulmonary small vessels. The correlation between the number of blood vessels in different levels of two-dimensional plane and LAA-950 was analyzed. Results there was a significant negative correlation between LAA-950 and LAA-950 in the apical segment of the right lung. Compared with the results of two scans in 48 patients with COPD, It was found that the number of blood vessels in smokers per unit area decreased more obviously than that in former smokers. Conclusion CT quantitative analysis of the number of small pulmonary vessels in patients with COPD is intuitionistic. Quantifiable benefits. Pulmonary vascularity in COPD patients is affected by smoking status and emphysema.
【作者单位】：西安交通大学第一附属医院PET/CT室;西安交通大学第一附属医院医学影像科;
【基金】：国家卫生和计划生育委员会公益性行业科研专项基金(201402013)
【分类号】：R816.41;R563.9

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