肌松剂在危重症哮喘机械通气中的疗效观察

发布时间：2018-03-06 14:34

本文选题：肌松剂　切入点：危重症哮喘　出处：《南京医科大学学报(自然科学版)》2015年02期 　论文类型：期刊论文

【摘要】：目的 :回顾性分析肌松剂对危重症哮喘患者机械通气疗效的影响。方法:41例危重症哮喘患者分为肌松组19例,无肌松组2例,肌松组给予肌松剂+常规治疗,无肌松剂组给予常规治疗。观察2组患者气管插管机械通气后2 h血气分析及气道压变化、拔管时间、住院时间;观察肌松剂使用时间48 h和48 h的哮喘患者拔管时间及住院时间。结果:肌松组在使用肌松剂2 h的p H值、Pa CO2较无肌松组明显好转(P0.05),气道峰值压力较无肌松组明显下降(P0.05),2组Pa O2无明显差异(P0.05)。肌松组拔管时间与无肌松组比较无统计学差异(P0.05),肌松组住院时间较无肌松组显著延长(P0.05)。肌松剂使用48 h与48 h相比,拔管时间及住院时间均显著延长(P0.05)。结论:肌松剂能迅速改善危重症哮喘患者机械通气后的p H值、Pa CO2,明显降低气道峰值压力,但肌松剂使用48 h会延长拔管时间及住院时间。
[Abstract]:Objective: to analyze retrospectively the effect of muscle relaxant on mechanical ventilation in patients with critical asthma. Methods: 41 patients with critical asthma were divided into two groups: muscle relaxation group (n = 19), no muscle relaxant group (n = 2), and muscle relaxant group (n = 2). Two hours after mechanical ventilation, blood gas analysis, airway pressure change, extubation time and hospitalization time were observed in the group without muscle relaxant. The extubation time and hospitalization time of asthmatic patients who were treated with muscle relaxant for 48 h and 48 h were observed. Results: the pH value of PA CO2 in the muscle relaxant group was significantly better than that in the no muscle relaxant group, and the peak airway pressure was higher than that in the no muscle relaxant group. There was no significant difference in PaO2 between the two groups. There was no significant difference in extubation time between the two groups. There was no significant difference in the extubation time between the two groups. The hospitalization time of the muscle relaxant group was significantly longer than that of the no muscle relaxant group. The use of muscle relaxant for 48 h was significantly longer than that for 48 h. The extubation time and hospitalization time were significantly prolonged (P 0.05). Conclusion: the pH value of Paco _ 2 after mechanical ventilation can be improved rapidly and the peak airway pressure can be significantly reduced in patients with severe asthma. However, 48 hours of use of muscle relaxant can prolong the extubation time and hospital stay.
【作者单位】：南京医科大学第一附属医院呼吸科RICU;
【分类号】：R562.25

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