丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察

发布时间：2018-03-06 17:43

本文选题：丹参多酚酸盐　切入点：慢性阻塞性肺疾病急性加重期　出处：《中国药房》2016年17期 　论文类型：期刊论文

【摘要】：目的:观察丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及安全性。方法:选取AECOPD患者80例,按随机数字表法分为观察组和对照组,各40例。两组患者均采用机械通气治疗。对照组患者根据病情给予茶碱、支气管扩张剂及糖皮质激素行常规治疗;观察组患者在对照组基础上给予丹参多酚酸盐注射液200 mg,qd,ivgtt。两组患者均治疗7 d。观察两组患者临床疗效及治疗前后患者血液流变学指标,并记录机械通气时间、重症加强护理病房(ICU)滞留时间及不良反应发生情况。结果:观察组患者临床总有效率为95.00%,显著高于对照组的70.00%,差异有统计学意义(P0.05)。治疗前及治疗后2 d,两组患者血液流变学指标比较,差异无统计学意义(P0.05);治疗后4、6 d,两组患者血液流变学指标均较治疗前有显著改善,且观察组显著优于对照组,差异有统计学意义(P0.05)。观察组患者机械通气时间和ICU滞留时间均显著短于对照组,差异有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:丹参多酚酸盐治疗AECOPD疗效显著,且安全性较好。
[Abstract]:Objective: to observe the clinical efficacy and safety of salvia miltiorrhiza polyphenolic acid salt in the treatment of chronic obstructive pulmonary disease (COPD) patients with acute exacerbation. Methods: 80 patients with AECOPD were randomly divided into two groups: observation group and control group. 40 patients in each group were treated with mechanical ventilation. Patients in the control group were treated with theophylline, bronchiectator and glucocorticoid according to their condition. The patients in the observation group were given salvia miltiorrhiza polyphenolic acid injection 200 mg / d iv gtt. both groups were treated for 7 days. The clinical efficacy and hemorheological indexes before and after treatment were observed, and the time of mechanical ventilation was recorded. Results: the total effective rate of the observation group was 95.00, which was significantly higher than that of the control group (70.005%). The difference was statistically significant before and 2 days after treatment. Comparison of hemorheological indexes, There was no significant difference between the two groups (P 0.05), and the hemorheology indexes of the two groups were significantly improved after 4 days of treatment, and the observation group was significantly better than the control group. The difference was statistically significant (P 0.05). The mechanical ventilation time and ICU retention time in the observation group were significantly shorter than those in the control group, and the difference was statistically significant (P 0.05). There were no significant adverse reactions in both groups. Conclusion: Salvianolic acid is effective in the treatment of AECOPD. And the safety is good.
【作者单位】：河北北方学院附属第一医院重症医学科;
【分类号】：R563.9

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