不同剂量替考拉宁治疗耐甲氧西林金黄色葡萄球菌感染呼吸机相关性肺炎的疗效研究

发布时间：2018-03-08 04:26

本文选题：替考拉宁　切入点：呼吸机相关性肺炎　出处：《中华医院感染学杂志》2014年02期 　论文类型：期刊论文

【摘要】：目的研究不同剂量替考拉宁治疗RICU耐甲氧西林金黄色葡萄球菌(MRSA)感染呼吸机相关性肺炎患者的临床疗效及安全性。方法选取RICU 2010年10月-2013年7月80例MRSA感染呼吸机相关性肺炎患者作为研究对象,随机分为试验组、对照组,每组各40例,试验组患者应用替考拉宁400mg,每12h1次,静脉滴注,连续3d后,改为400mg每日1次;对照组应用替考拉宁第1天400mg每12h1次,后改为每日1次,静脉滴注,疗程14d;观察治疗前后两组患者的临床症状及体征、影像学改变、临床疗效、细菌清除率及不良反应,进行疗效分析及安全性评价。结果试验组患者临床治疗有效率为82.5%,细菌清除率为70.0%,不良反应发生率为5.0%;对照组分别为75.0%、52.5%、5.0%,两组间细菌清除率及临床有效率差异有统计学意义(P0.05),不良反应发生率差异无统计学意义。结论初始高剂量加维持量替考拉宁治疗方案治疗MRSA感染呼吸机相关性肺炎疗效较好,且安全可靠。
[Abstract]:Objective to study the clinical efficacy and safety of different doses of teicoplanin in the treatment of ventilator-associated pneumonia infected with RICU methicillin-resistant staphylococcus aureus. Methods from October 2010 to July 2013, 80 cases of RICU infected with MRSA were selected. Patients with machine-associated pneumonia were studied. The patients in the experimental group were given teicoplanin 400 mg once every 12 h, intravenous drip was given once every 3 days, and the control group was treated with teicoplanin 400 mg once every 12 h once a day, and the control group was treated with teicoplanin once every 12 h, and the control group was treated with teicoplanin 400 mg once every 12 hours per day, and the control group was treated with teicoplanin 400 mg every 12 h once a day. The clinical symptoms and signs, imaging changes, clinical efficacy, bacterial clearance rate and adverse reactions of the two groups were observed before and after the treatment. Results the effective rate of clinical treatment was 82.5%, the clearance rate of bacteria was 70.0%, the incidence of adverse reactions was 5.0% in the experimental group, and that in the control group was 75.0% and 52.5%, respectively. The difference of bacterial clearance rate and clinical effective rate between the two groups was significant. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion the initial high dose and maintenance dose teicoplanin regimen is effective in the treatment of ventilator-associated pneumonia with MRSA infection. And safe and reliable.
【作者单位】：湖州市中心医院呼吸内科;
【基金】：浙江省卫生厅科技计划A类基金项目(2011KYA153)
【分类号】：R563.1

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