痰热清注射液对心力衰竭伴肺部感染患者血清胆碱酯酶及免疫功能的影响研究

发布时间：2018-03-09 13:11

本文选题：痰热清注射液　切入点：心力衰竭　出处：《中华医院感染学杂志》2017年22期 　论文类型：期刊论文

【摘要】：目的探讨痰热清注射液对心力衰竭伴肺部感染患者血清胆碱酯酶及免疫功能的影响。方法选取2013年3月-2015年8月医院符合标准的心力衰竭伴肺部感染患者90例,按随机数字表法分为2组,每组45例,对照组患者采用头孢哌酮/舒巴坦治疗,研究组在此基础上采用痰热清注射液治疗,持续1周,治疗前和治疗1周后采肘静脉血测定T淋巴细胞亚群(CD_8~+、CD_4~+/CD_8~+)、免疫球蛋白(IgG、IgM)和CHE、BNP、NT-proBNP等,测定心功能指标,同时比较临床疗效及不良反应。结果对照组总有效率为77.78%低于研究组的93.33%,差异有统计学意义(P0.05);与治疗前比较,两组治疗1周后T淋巴细胞亚群(CD_8~+、CD_4~+/CD_8~+)和免疫球蛋白(IgG、IgM)升高,CHE升高,BNP、NT-proBNP降低,LAD、LVEDD、LVESD降低,LVEF升高(P0.05);与对照组比较,研究组治疗1周后T淋巴细胞亚群(CD_8~+、CD_4~+/CD_8~+)和免疫球蛋白(IgG、IgM)较高,CHE较高,BNP、NT-proBNP较低,CHE较高,LAD、LVEDD、LVESD较低,LVEF较高(P0.05);两组不良反应发生率比较,差异无统计学意义。结论痰热清注射液治疗心力衰竭伴肺部感染,有利于提高免疫功能和心功能,降低心肌损伤,且对肝/肾无影响,可作为临床治疗方案推广。
[Abstract]:Objective to investigate the effect of Tanreqing injection on serum cholinesterase and immune function in patients with heart failure and pulmonary infection. The patients in the control group were treated with cefoperazone / sulbactam, and the study group was treated with Tanreqing injection for 1 week. Before and one week after treatment, T lymphocyte subsets were measured by T lymphocyte subsets and CD8 / CD8 / CD8, IgG / IgM and CHEBNPNT-proBNP, respectively. Cardiac function was measured. Results the total effective rate of the control group was 77.78% lower than that of the study group 93.33 (P 0.05). After one week of treatment, the T lymphocyte subsets CD8 / CD8 and IgG / IgM were increased, and BNPNT-proBNP decreased, LVEDDLVESD decreased LVEF and LVEF increased P0.05 compared with the control group, After one week of treatment, the T lymphocyte subsets in the study group were higher than those in the study group. The incidence of adverse reactions in the two groups was higher, the incidence of adverse reactions was higher, the incidence of adverse reactions was higher, the incidence of adverse reactions in the two groups was higher, the incidence of adverse reactions in the two groups was higher than that in the patients with higher BNPE, higher NT-proBNP, higher che, lower LVEDDD, LVESD, and higher LVEF, and the incidence of adverse reactions was higher in the study group than in the control group, and the incidence of adverse reactions was higher in the two groups. Conclusion Tanreqing injection in the treatment of heart failure with pulmonary infection is beneficial to improve immune function and cardiac function, reduce myocardial injury, and have no effect on liver / kidney.
【作者单位】：江苏省连云港市东海县人民医院心血管内科;江苏省连云港市东海县人民医院护理部;江苏省连云港市东海县人民医院药剂科;
【基金】：江苏省卫生厅科研基金资助项目(P201520)
【分类号】：R541.6;R563.1

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