血清白细胞介素-6、触珠蛋白及淀粉样蛋白A对慢性阻塞性肺疾病患者肺部感染的鉴别诊断研究

发布时间：2018-03-10 15:17

本文选题：慢性阻塞性肺疾病　切入点：肺部感染　出处：《中华医院感染学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的探究慢性阻塞性肺疾病并发肺部感染患者血清白细胞介素-6(IL-6)、触珠蛋白(HPT)、淀粉样蛋白A(SAA)水平,为慢性阻塞性肺疾病并发肺部感染提供诊断依据。方法选取2014年1月-2016年1月医院接受治疗的354例慢性阻塞性肺疾病患者为研究对象,其中并发肺部感染的92例患者为A组,262例未发生肺部感染的患者为B组,选取354名健康体检者为C组;对A组患者进行菌落培养并鉴定肺部感染病原菌种类;采用酶联免疫吸附试验对三组研究者血清白细胞介素-6进行测定并加以比较;使用双光径免疫浊度分析仪检测三组研究者触珠蛋白以及淀粉样蛋白A水平;将A组患者根据是否患有呼吸衰竭分为慢性阻塞性肺疾病非加重患者和加重患者,比较两组患者以上指标含量水平;运用ROC曲线测定血清白细胞介素-6、触珠蛋白以及淀粉样蛋白A对慢性阻塞性肺疾病并发肺部感染的诊断价值。结果 A组的92例患者共检出病原菌164株,其中革兰阳性菌36株占22.0%、革兰阴性菌107株占65.2%、真菌14株占8.6%、其他菌种7株占4.3%;A组患者血清IL-6含量为114.42±17.82ng/L、HPT含量为1.88±0.36g/L、SAA含量为271.05±22.45g/L,B组患者血清IL-6含量为83.46±15.59ng/L、HPT含量为1.56±0.24g/L、SAA含量为225.49±20.68g/L,C组研究者IL-6含量为31.03±19.71ng/L、HPT含量为0.89±0.21g/L、SAA含量为48.24±19.37g/L,三组数据比较差异具有统计学意义(P0.05);并发肺部感染的患者中,加重患者血清IL-6、HPT以及SAA水平均高于非加重患者。结论血清白细胞介素-6、触珠蛋白以及淀粉样蛋白A均可对慢性阻塞性肺疾病并发肺部感染进行预测,临床可加以控制。
[Abstract]:Objective to investigate the serum levels of interleukin-6 (IL-6) IL-6, haptoglobin (HPTT) and amyloid protein (Agna) in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection. Methods 354 patients with chronic obstructive pulmonary disease (COPD) received hospital treatment from January 2014 to January 2016 were selected as subjects. Among them, 92 patients complicated with pulmonary infection were group A (262 patients without pulmonary infection) and 354 healthy persons (group C). The levels of serum interleukin-6 (IL-6) and amyloid A (amyloid A) in the three groups were measured by enzyme-linked immunosorbent assay (Elisa). The patients in group A were divided into two groups: chronic obstructive pulmonary disease (COPD) patients without exacerbation and patients with exacerbation according to whether they had respiratory failure, and the above indexes were compared between the two groups. The diagnostic value of serum interleukin-6 (IL-6), globin and amyloid A (amyloid A) in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary infection was determined by ROC curve. Results in group A, 164 strains of pathogenic bacteria were detected in 92 patients with chronic obstructive pulmonary disease (COPD). Among them, 36 Gram-positive bacteria accounted for 22.0%, 107 Gram-negative bacteria accounted for 65.2, 14 fungi accounted for 8.6am, and other 7 strains accounted for 4.3A, the serum IL-6 content was 114.42 卤17.82ng / L HPT 1.88 卤0.36g / L LSAA = 271.05 卤22.45g / L LSAA = 83.46 卤15.59ng / L / L HPT = 1.56 卤0.24g / L LSAA = 225.49 卤20.68g / L LSAA = 225.49 卤20.68g / L LSAA. The IL-6 content of the three groups was 31.03 卤19.71 ng / L, 0.89 卤0.21 g / L, 48.24 卤19.37 g / L, respectively. The difference among the three groups was statistically significant (P 0.05). The serum levels of IL-6 HPT and SAA in patients with exacerbation were higher than those in patients without exacerbation. Conclusion Serum interleukin-6, globin and amyloid A can be used to predict pulmonary infection in patients with chronic obstructive pulmonary disease and can be controlled clinically.
【作者单位】：湖北医药学院附属人民医院呼吸内科;
【分类号】：R563

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