布地奈德对COPD急性发作期肺泡灌洗液中IL-8表达的影响

发布时间：2018-03-10 15:36

本文选题：慢性阻塞性肺病　切入点：支气管肺泡灌洗液　出处：《中国卫生检验杂志》2014年19期 　论文类型：期刊论文

【摘要】：目的探讨COPD患者BALF中IL-8水平及布地奈德对其调节作用。方法选择本科2009年7月-2013年7月COPD急性发作期患者按就诊时间分为常规组和治疗组各60例。常规组予综合治疗,治疗组在此基础上进行布地奈德雾化吸入治疗,疗程均为3周,对2组治疗前、治疗1周、治疗3周BALF中IL-8水平进行检测,并与GOLD分级进行相关性分析。结果治疗前、治疗1周、治疗3周IL-8浓度常规组分别为(9.68±1.46)pg/ml、(9.45±1.63)pg/ml、(8.70±2.00)pg/ml,治疗组分别为(9.35±1.49)pg/ml、(8.75±1.57)pg/ml、(6.27±1.96)pg/ml,治疗前2组差异无统计学意义(P0.05);治疗1周后2组差异有统计学意义(P0.05),治疗3周后2组差异有统计学意义(P0.01);BALF中IL-8水平与GOLD分级呈正相关(r=0.519,P0.01)。结论 COPD患者BALF中IL-8能反映COPD气道炎症情况,布地奈德能显著降低BALF中IL-8水平。
[Abstract]:Objective to investigate the level of IL-8 in BALF of patients with COPD and the regulatory effect of budesonide. Methods patients with acute attack of COPD from July 2009 to July 2013 were divided into routine group (n = 60) and treatment group (n = 60). The treatment group was treated with budesonide atomization inhalation for 3 weeks. The levels of IL-8 in BALF were measured before treatment, 1 week after treatment and 3 weeks after treatment in both groups, and the correlation between IL-8 and GOLD grade was analyzed. 1 week of treatment, After 3 weeks of treatment, the IL-8 concentration of routine group was 9.68 卤1.46 mg / ml 9.45 卤1.63 mg / ml 8.70 卤2.00 g / ml, and that of treatment group was 9.35 卤1.49 g / ml 8.75 卤1.57g / ml 6.27 卤1.96pg / ml respectively. There was no significant difference between the two groups before and after treatment (P 0.05%), and there was significant difference in IL-8 water in group 2 after 3 weeks of treatment. Conclusion IL-8 in BALF of COPD patients can reflect the airway inflammation of COPD. Budesonide could significantly reduce the level of IL-8 in BALF.
【作者单位】：台州市恩泽医疗集团路桥医院急诊科;台州市恩泽医疗集团路桥医院儿科;台州市恩泽医疗集团路桥医院呼吸科;
【基金】：台州市科技局资助课题(11ky34);台州市科技局资助课题(1301ky49) 路桥区科技局资助课题(2011A2-3010)
【分类号】：R563.9

【参考文献】