降钙素原测定在间质性肺疾病合并细菌感染诊断中的价值

发布时间：2018-03-12 17:04

本文选题：间质性肺疾病　切入点：降钙素原　出处：《兰州大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过比较降钙素原与传统炎性指标,探讨降钙素原在间质性肺疾病合并细菌感染中的诊断价值。方法:本实验针对所入选患者采取回顾性资料比较的方法,进行系统性研究分析。搜集了兰州大学第一医院于2014年1月份到2016年3月份期间在呼吸内科住院治疗的间质性肺疾病患者。患者在入院时行胸部HRCT、血常规、血气分析、血清CRP和血清PCT等检查,同时留痰标本、血培养行病原学检查。通过分析入选患者的临床症状及体征、检查结果等将入选病例分为两组:间质性肺疾病合并细菌感染组与非感染性间质性肺疾病组,进而比较降钙素原与其他炎性指标(白细胞计数、中性粒细胞百分比、C-反应蛋白)在诊断间质性肺疾病合并细菌感染的价值。结果:共77例间质性肺疾病患者入选为观察对象,其中间质性肺疾病合并细菌感染组46例,非感染性间质性肺疾病组31例。间质性肺疾病合并细菌感染患者与非感染性间质性肺疾病患者相比,血清PCT[(0.74±0.31)ng/ml vs(0.17±0.11)ng/ml,P0.01];诊断间质性肺疾病合并细菌感染的ROC曲线下面积PCT 0.979±0.012,在最佳截断值时的灵敏度为93.5%,特异度为93.5%。结论:降钙素原与其他炎性指标在诊断间质性肺疾病合并细菌感染时都有一定的诊断意义,但降钙素原检测可显著提高间质性肺疾病合并细菌感染的诊断准确率,具有高灵敏度和高特异性.
[Abstract]:Objective: to investigate the diagnostic value of procalcitonin in interstitial lung disease with bacterial infection by comparing procalcitonin with traditional inflammatory markers. The patients with interstitial lung disease who were hospitalized in Department of Respiratory Medicine from January 2014 to March 2016 were collected from the first Hospital of Lanzhou University. The patients received chest HRCT, blood routine examination, blood gas analysis on admission. Serum CRP and serum PCT were examined, while sputum samples were kept and blood culture was performed for etiological examination. The clinical symptoms and signs of the selected patients were analyzed. The patients were divided into two groups: interstitial pulmonary disease with bacterial infection group and non-infectious interstitial lung disease group, and then compared procalcitonin with other inflammatory markers (white blood cell count, leukocyte count, leukocyte count, leukocyte count, leukocyte count, leukocyte count, leukocyte count, leukocyte count, leukocyte count, The value of neutrophil percentage of C-reactive protein in the diagnosis of interstitial lung disease with bacterial infection. Results: a total of 77 patients with interstitial lung disease were included in the study group, 46 patients with interstitial lung disease complicated with bacterial infection. 31 patients with noninfectious interstitial pulmonary disease were compared with those with noninfectious interstitial pulmonary disease. Serum PCT [0.74 卤0.31 ng / ml vs(0.17 卤0.11 ng / ml P0.01]; area under ROC curve for diagnosis of interstitial pulmonary diseases with bacterial infection PCT 0.979 卤0.012, sensitivity 93.5G and specificity 93.5g at the best truncation value. Conclusion: procalcitonin and other inflammatory markers in the diagnosis of interstitial pulmonary diseases complicated by interstitial pulmonary diseases. When bacteria are infected, they have some diagnostic significance. But the detection of procalcitonin can significantly improve the diagnostic accuracy of interstitial lung disease with bacterial infection, and has high sensitivity and specificity.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563

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