干扰素释放试验在AIDS合并结核感染患者中的诊断价值

发布时间：2018-03-16 20:10

本文选题：获得性免疫缺陷综合征　切入点：HIV　出处：《重庆医学》2015年11期 　论文类型：期刊论文

【摘要】：目的评价4种诊断方法对人获得性免疫缺陷综合征(AIDS)合并结核病(TB)患者的诊断价值。方法将52例人类免疫缺陷病毒(HIV)感染合并TB患者作为观察组,100例未感染HIV的TB患者为对照组,对两组患者进行结核菌素(PPD)试验、痰结核菌培养、结核抗体和γ干扰素释放试验(IGRA)进行诊断。结果对照组患者PPD试验、痰结核菌培养和结核抗体阳性率明显高于观察组患者,差异有统计学意义(P0.01);而IGRA阳性率两组比较,差异无统计学意义(P0.05);观察组IGRA阳性明显高于PPD试验、痰结核菌培养和结核抗体阳性率,均差异有统计学意义(P0.01)。抗逆转录病毒治疗观察组患者IGRA阴性发生率明显高于阳性率,差异有统计学意义(P0.05)。结论 IGRA是诊断HIV感染合并TB的敏感方法,而抗逆转录病毒治疗可能对结果有一定的影响。
[Abstract]:Objective to evaluate the diagnostic value of four diagnostic methods in patients with acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB). TB patients as control group, Two groups of patients were diagnosed by tuberculin test, sputum culture, tuberculosis antibody and interferon 纬 release test (IGRAA). Results the positive rates of PPD test, sputum culture and tuberculosis antibody in the control group were significantly higher than those in the observation group. The positive rate of IGRA in the observation group was significantly higher than that in the PPD test, and the positive rate of tuberculous bacilli in sputum and tuberculosis antibody was higher in the observation group than that in the control group, while there was no significant difference in the positive rate of IGRA between the two groups. The negative rate of IGRA in the antiretrovirus treatment group was significantly higher than that in the positive group, and the difference was statistically significant (P 0.05). Conclusion IGRA is a sensitive method for the diagnosis of HIV infection with TB. Antiretroviral therapy may have an effect on the outcome.
【作者单位】：石家庄市第五医院结核科/石家庄市结核病防治研究所;
【基金】：石家庄科学技术研究与发展计划基金项目(121461833) 河北省科技技术研究与发展计划项目(12277746)
【分类号】：R521;R512.91

【参考文献】