免疫治疗对重症肺炎患者免疫功能指标的影响研究

发布时间：2018-03-17 13:08

本文选题：重症肺炎　切入点：免疫治疗　出处：《中国现代药物应用》2016年17期 　论文类型：期刊论文

【摘要】：目的分析免疫治疗对重症肺炎患者免疫功能指标影响,评价免疫治疗价值。方法 90例重症肺炎患者,随机分为对照组和观察组,各45例。均给予常规法除病因、抗感染、支持治疗,观察组联合胸腺肽治疗,比较相关指标。结果治疗后1周,对照组外周血淋巴细胞计数、CD4+/CD8+、NK细胞激活率、血清白介素-2(IL-2)、免疫球蛋白Ig A水平为(2.3±0.5)×109、(1.4±0.3)、(16.1±7.5)%、(2.2±1.1)ng/L、(2.1±0.8)g/L,观察组则为(1.9±0.4)×109、(1.2±0.5)、(16.0±5.7)%、(2.2±0.9)ng/L、(2.1±0.9)g/L,观察组与对照组外周血淋巴细胞计数、CD4+/CD8+低于治疗前,观察组低于对照组,差异均具有统计学意义(P0.05),观察组与对照组NK、IL-2、Ig A水平组间比较差异无统计学意义(P0.05)。结论对重症肺炎患者开展免疫治疗,可调节T细胞群,调节免疫功能。
[Abstract]:Objective to analyze the effect of immunotherapy on immune function in patients with severe pneumonia and evaluate the value of immunotherapy. Methods 90 patients with severe pneumonia were randomly divided into control group and observation group with 45 cases each. Results 1 week after treatment, the peripheral blood lymphocyte count of the control group and the activation rate of CD4 / CD8 + NK cells were observed. The levels of serum interleukin-2ng-1, immunoglobulin IgA were 2.3 卤0.5) 脳 109ng / L = 1.4 卤0.3ng / L, 16.1 卤7.5ng / L = 2.2 卤1.1 ng / L, 2.1 卤0.8g / L, respectively, and those in the observation group were 1.9 卤0.4) 脳 1091.2 卤0.50.70 卤5.7g / L respectively. The peripheral blood lymphocyte counts of the observation group and the control group were lower than those of the control group before treatment, and those of the observation group were lower than those of the control group, and the peripheral blood lymphocyte counts of the observation group and the control group were lower than those of the control group. The difference was statistically significant (P 0.05), but there was no significant difference between the observation group and the control group (P 0.05). Conclusion Immunotherapy can regulate T cell group and immune function in patients with severe pneumonia.
【作者单位】：大连市中心医院呼吸内科;
【分类号】：R563.1

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