血必净协同治疗对于慢性阻塞性肺疾病急性加重期患者临床肺部感染评分、炎症标记物及免疫功能的影响

发布时间：2018-03-19 21:18

本文选题：血必净注射液　切入点：慢性阻塞性肺疾病加重期　出处：《中华中医药学刊》2017年05期 　论文类型：期刊论文

【摘要】：目的:评价血必净注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床肺部感染评分(Clinical pulmonary infection score,CPIS)、炎症标记物及免疫功能的影响以及其临床疗效。方法:将78例AECOPD患者随机分为两组(治疗组和对照组),每组均为39例,两组均予常规抗炎、解痉平喘、祛痰治疗,治疗组加用生理盐水250 m L+血必净注射液100 m L 1次/d静脉滴注,疗程为10 d。观察两组的临床疗效、记录治疗前后两组患者的CPIS评分并检测患者血清中炎症标记物(C反应蛋白CRP、降钙素原PCT、白细胞总数WBC)及免疫功能(CD_3、CD_4、CD_8、CD_4/CD_8)的变化。结果:治疗后,治疗组与对照组患者所有观察指标均较治疗前明显改善(P0.05)。治疗后除白细胞总数差异无统计学意义外(P0.05),治疗组在治疗后总有效率、CRP、PCT、CD_3、CD_4、CD_8、CD_4/CD_8均明显优于对照组,且差异具有统计学意义(P0.05)。结论:临床应用血必净注射液协同治疗AECOPD,能提高患者免疫功能,减轻炎症反应,明显提高治疗有效率。
[Abstract]:Objective: To evaluate the effect of Xuebijing Injection on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with clinical pulmonary infection score (Clinical pulmonary, infection score, CPIS), effect of markers of inflammation and immune function and its clinical curative effect. Methods: 78 cases of AECOPD patients were randomly divided into two groups (treatment group and control group), each group had 39 cases, two groups were given conventional anti-inflammatory, antispasmodic, expectorant treatment, the treatment group was treated with saline 250 m L+ L 100 m Xuebijing injection 1 /d intravenous infusion for the treatment of 10 d. to observe the clinical curative effect of two groups, recording two groups before and after treatment CPIS score and serum inflammation patients with detection of markers (C reactive protein CRP, procalcitonin PCT, the total number of white blood cells and immune function (WBC) of CD_3, CD_4, CD_8, CD_4/CD_8) changes. Results: after the treatment, the treatment group and the control group were all observed indicators were significantly changed Good (P0.05). After the treatment except WBC differences were not statistically significant (P0.05), the total efficiency of the treatment group after treatment, CRP, PCT, CD_3, CD_4, CD_8, CD_4/CD_8 were significantly better than the control group, and the difference was statistically significant (P0.05). Conclusion: the clinical application of blood will net injection with the treatment of AECOPD, can improve the immune function of patients, reduce inflammation, improve the treatment efficiency.

【作者单位】：辽宁中医药大学附属医院;
【基金】：辽宁省科技厅项目(2011225016)
【分类号】：R563.9

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