不同方案治疗复治肺结核的疗效评价

发布时间：2018-03-20 19:16

本文选题：结核/肺　切入点：药物治疗　出处：《广东医学》2017年15期 　论文类型：期刊论文

【摘要】：目的评价不同治疗方案对复治肺结核患者的治疗效果。方法采用前瞻性队列研究方法,收集收治的167例复治涂阳肺结核患者,分为4组并分别采用不同治疗方案进行治疗,比较各组治疗效果、不良反应发生率及复发情况。结果 3个试验组患者在病灶吸收、痰菌阴转、成功治疗率和复发率等方面均优于对照组,其中高剂量组、长疗程组和个体化方案组满疗程痰菌阴转率分别为91.1%、92.5%和90.0%,高于对照组(71.4%),各组间差异有统计学意义(X~2=9.63,P=0.02)。高剂量组、长疗程组、个体化方案组和对照组治疗成功率分别为91.1%、90.0%、87.5%和71.4%,各组间差异有统计学意义(X~2=8.38,P=0.04)。患者在治疗过程中3个试验组不良反应发生率均高于对照组,但差异无统计学意义。结论不同化疗方案对复治肺结核患者的治疗效果有一定的差异,其中以高剂量和长疗程治疗方案疗效较好。
[Abstract]:Objective to evaluate the effect of different treatment schemes on patients with recurrent pulmonary tuberculosis. Methods 167 patients with re-treated smear positive pulmonary tuberculosis were collected by prospective cohort study and divided into 4 groups and treated with different treatment schemes. Results the three groups were superior to the control group in terms of focus absorption, sputum negative conversion, successful treatment rate and recurrence rate, among which the high dose group was superior to the control group. The sputum negative conversion rates of the long course group and the individualized group were 92.5% and 90.0% respectively, which were higher than that of the control group (71.4%). The success rate of individual regimen group and control group were 91.1% and 71.4%, respectively. The difference was statistically significant. The incidence of adverse reactions in the three test groups was higher than that in the control group. Conclusion there are some differences in the therapeutic effects of different chemotherapy regimens on patients with recurrent pulmonary tuberculosis, among which the high dose and long course of treatment are better.
【作者单位】：广东省结核病控制中心门诊部;广东省佛山市第四人民医院防治科;
【基金】：“十一五”国家科技重大专项(编号:2008ZX10003-015) “十二五”国家科技重大专项(编号:2013ZX10003009-007)
【分类号】：R521

【相似文献】