无创正压通气治疗老年肺癌重症呼吸衰竭患者的临床疗效

发布时间：2018-03-20 21:58

本文选题：肺肿瘤　切入点：老年人　出处：《中国肿瘤临床与康复》2015年09期 　论文类型：期刊论文

【摘要】：目的探讨无创正压通气治疗老年肺癌重症呼吸衰竭患者的临床疗效。方法选取2011年6月至2014年6月间收治的老年肺癌合并重症呼吸衰竭患者102例,按照随机数字表法分为观察组和对照组,每组51例。观察组患者在常规治疗基础上接受经鼻罩双水平无创正压通气治疗,对照组患者仅接受常规治疗,观察两组患者治疗后2 h、24 h后血气分析情况、治疗第14天后的疗效以及随访30 d和180 d时患者基本情况的改善情况,并对相关数据进行比较。结果治疗2 h后,观察组患者p H、动脉血二氧化碳分压(Pa CO2)、血氧分压(Pa O2)较治疗前明显改善(P0.05),对照组患者p H、Pa CO2、Pa O2指标改善不明显(P0.05);治疗24 h后,两组患者各指标均有所改善,但对照组患者各项指标改善幅度低于观察组,差异有统计学意义(P0.05);治疗第14天后,观察组患者的治疗总有效率为92.2%,显著高于对照组的66.7%,差异有统计学意义(P0.05);治疗后30 d和随访180 d时,观察组患者基本情况改善显著优于对照组,差异有统计学意义(P0.05)。结论无创正压通气治疗老年肺癌重症呼吸衰竭患者效果显著,改善了患者的生活情况,提高了患者的生活质量,值得临床进一步研究。
[Abstract]:Objective to investigate the clinical efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of elderly patients with severe respiratory failure of lung cancer. Methods 102 cases of elderly patients with lung cancer complicated with severe respiratory failure from June 2011 to June 2014 were selected. According to the random number table method, the patients in the observation group and the control group were divided into observation group and control group with 51 cases in each group. The patients in the observation group received bilevel non-invasive positive pressure ventilation via nasal mask on the basis of routine treatment, while the patients in the control group received only routine treatment. To observe the blood gas analysis after 2 hours and 24 hours after treatment, the curative effect after 14 days treatment and the improvement of the basic condition of the patients at 30 and 180 days follow-up, and to compare the relevant data. Results after 2 hours of treatment, the results were compared. Compared with before treatment, the patients in the observation group were significantly improved (P 0.05), while the patients in the control group were not significantly improved (P 0.05), and after 24 hours of treatment, all the indexes were improved in both groups, and the changes were not significant in the control group (P < 0.05), but in the control group, there was no significant difference between the two groups after 24 hours of treatment, there was no significant difference between the two groups after 24 hours of treatment, there was no significant difference between the two groups. However, the improvement range of the indexes in the control group was lower than that in the observation group, and the difference was statistically significant (P 0.05). The total effective rate of treatment in the observation group was 92. 2%, which was significantly higher than that in the control group (66. 7%), the difference was statistically significant (P 0. 05%), and the basic condition of the observation group was significantly better than that of the control group 30 days after treatment and 180 days after follow-up. Conclusion Non-invasive positive pressure ventilation in the treatment of elderly lung cancer patients with severe respiratory failure has a significant effect, improve the living conditions of patients, improve the quality of life of patients, worthy of further clinical research.
【作者单位】：四川省都江堰市人民医院重症医学科;
【分类号】：R734.2

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