不同风险慢性阻塞性肺疾病患者戒烟干预后临床症状及肺功能变化研究

发布时间：2018-03-22 17:53

本文选题：肺疾病　切入点：慢性阻塞性　出处：《中国全科医学》2014年01期 　论文类型：期刊论文

【摘要】：目的探讨不同风险慢性阻塞性肺疾病(COPD)患者戒烟干预对其临床症状及肺功能的影响,为不同风险的吸烟COPD患者的防治提供依据。方法将我院稳定期吸烟COPD患者109例随机分为戒烟干预组和对照组,按肺功能分级及入组前1年急性加重次数分别将戒烟干预组、对照组分为戒烟干预低风险组(30例)、戒烟干预高风险组(25例)和对照低风险组(33例)、对照高风险组(21例)4个亚组,对4组患者进行为期1年的追踪随访,戒烟干预组在常规治疗基础上进行戒烟干预,对照组给予常规治疗,比较患者入组时、1年后临床症状评分和1 s用力呼气容积(FEV1)。结果随访满1年时,戒烟干预低风险组症状评分变化量为(2.23±0.86)分,对照低风险组为(1.39±0.70)分,戒烟干预低风险组临床症状的改善优于对照低风险组,差异有统计学意义(P0.001);戒烟干预低风险组FEV1变化量为(0.060±0.429)L,对照低风险组为(0.335±0.406)L,对照低风险组FEV1的下降高于戒烟干预低风险组,差异有统计学意义(P=0.011)。戒烟干预高风险组症状评分变化量为(2.72±0.89)分,对照高风险组为(1.86±0.65)分,戒烟干预高风险组临床症状的改善优于对照高风险组,差异有统计学意义(P=0.001);戒烟干预高风险组FEV1变化量为(0.012±0.138)L,对照高风险组为(0.127±0.144)L,对照高风险组FEV1的下降高于戒烟干预高风险组,差异有统计学意义(P=0.008)。结论戒烟干预可以明显改善吸烟COPD患者的临床症状、延缓其FEV1下降,随访及戒烟干预对吸烟的高风险COPD患者改善临床症状、降低急性加重风险更具有临床意义。
[Abstract]:Objective to investigate the effects of smoking cessation intervention on clinical symptoms and pulmonary function in patients with different risks of chronic obstructive pulmonary disease (COPD). Methods 109 COPD patients with stable smoking in our hospital were randomly divided into smoking cessation intervention group and control group. According to the grade of pulmonary function and the number of acute exacerbations before one year before entering the group, the patients in the intervention group were divided into two groups. The control group was divided into 4 subgroups: 30 cases of low risk group, 25 cases of high risk group), 33 cases of low risk group and 21 cases of high risk group). The four groups were followed up for one year. Smoking cessation intervention group was given smoking cessation intervention on the basis of routine therapy, while the control group was given routine therapy. The clinical symptom score and forced expiratory volume of 1 s were compared after 1 year after the patients entered the group. Results at the end of one year, the patients were followed up for 1 year. The change of symptom score was 2.23 卤0.86 in the low risk group and 1.39 卤0.70 in the control group. The improvement of clinical symptoms in the low risk group was better than that in the low risk control group. The change of FEV1 was 0.060 卤0.429 L in the low risk group and 0.335 卤0.406 L in the control group. The decrease of FEV1 in the control low risk group was higher than that in the low risk group. The change of symptom score in high risk group was 2.72 卤0.89, and that in high risk group was 1.86 卤0.65. The improvement of clinical symptoms in high risk group was better than that in high risk group. The change of FEV1 was 0.012 卤0.138 L in high risk group and 0.127 卤0.144 L in high risk group. The decrease of FEV1 in high risk group was higher than that in high risk group. Conclusion smoking cessation intervention can significantly improve the clinical symptoms and delay the decrease of FEV1 in patients with smoking COPD. Follow-up and smoking cessation intervention can improve the clinical symptoms of patients with high risk of smoking COPD. Reducing the risk of acute exacerbation is of clinical significance.
【作者单位】：承德医学院附属医院呼吸科;北京大学人民医院呼吸科;
【基金】：中华医学会临床医学慢性呼吸道疾病科研专项资金(07010260034)
【分类号】：R563.9

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