咳嗽变异性哮喘与典型支气管哮喘患者外周血树突状细胞的变化

发布时间：2018-03-22 18:33

本文选题：典型支气管哮喘　切入点：咳嗽变异性哮喘　出处：《暨南大学学报(自然科学与医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的:计算咳嗽变异性哮喘(CVA)、典型支气管哮喘(CA)患者,其外周血中树突状细胞(DCs)及亚型髓样树突状细胞(m DC)、浆细胞样树突状细胞(p DC)比例和数量的变化,了解咳嗽变异性哮喘与典型支气管哮喘之间是否有类似的免疫学发病机制.方法:选取CA患者20例,CVA患者17例,对照组健康人17例,使用流式细胞术检测和计算CA组与CVA组受试者外周血中DCs及其两个亚群:p DC和m DC所占比例和数量的变化.结果:咳嗽变异性哮喘与典型支气管哮喘患者相比,其外周血树突状细胞及其亚型的数量和比例均无明显差异,咳嗽变异性哮喘、典型支气管哮喘患者较健康对照组,p DC数量及比例的增高明显,m DCs/p DCs的比值降低有统计学差异.结论:咳嗽变异性哮喘与支气管哮喘的发病机制在免疫学上类似,由于p DCs比例和数量的增多引起Th2细胞数量增多,造成Th1/Th2平衡向Th2细胞偏移.
[Abstract]:Objective: to calculate the percentage and quantity of dendritic cells (DCs), myeloid dendritic cells (MDC) and plasma cell-like dendritic cells (PDC) in the peripheral blood of patients with cough variant asthma (CVA) and typical bronchial asthma (CAA). Methods: 20 patients with CA and 17 patients with CVA were selected as control group. Flow cytometry was used to detect and calculate the percentage and quantity of DCs and its two subgroups in peripheral blood of patients with CA and CVA. Results: cough variant asthma was compared with typical bronchial asthma patients. There was no significant difference in the number and proportion of dendritic cells and their subtypes in peripheral blood. Compared with the control group, the number and proportion of DCs/p DC in typical bronchial asthma patients increased significantly and the ratio of m DCs/p DCs decreased significantly. Conclusion: the pathogenesis of cough variant asthma and bronchial asthma is similar in immunology. The proportion and number of p DCs increased the number of Th2 cells, which resulted in the shift of Th1/Th2 balance to Th2 cells.
【作者单位】：华中科技大学同济医学院附属武汉中心医院呼吸内科;
【基金】：武汉市卫计委基金(WX16C45)
【分类号】：R562.25

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