高血压患者上呼吸道感染鲍曼不动杆菌的耐药机制分析

发布时间：2018-03-23 01:29

本文选题：高血压患者　切入点：呼吸道感染　出处：《中国病原生物学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的研究高血压患者上呼吸道感染鲍曼不动杆菌耐药基因及耐药性变迁情况,为临床感染性疾病的预防和控制提供指导。方法收集本院高血压上呼吸道感染患者痰液标本,分离鲍曼不动杆菌,K-B法进行耐药性分析,PCR扩增法进行耐药基因检测。结果 2013-2015年共分离鲍曼不动杆菌377株,各菌株对氨曲南耐药率100%,对头孢吡肟、头孢噻肟、头孢他啶、左氧氟沙星和氨苄西林耐药率分别为77.98%、77.45%、77.98%、70.56%和74.27%,对阿米卡星和亚胺培南耐药率分别为35.28%和34.22%。377株鲍曼不动杆菌OXA-23、OXA-58、TEM、PER、IMP和CTX-M-9等耐药基因阳性菌株分别为141、44、133、68、61和22株,阳性率分别为37.40%、11.67%、35.28%、18.04%、16.18%和5.84%。2013-2015年各年度鲍曼不动杆菌OXA-23、OXA-58、TEM、PER、IMP、CTX-M-9基因阳性率分别为27.36%、4.72%、32.08%、16.04%、9.43%、3.77%,32.28%、11.81%、34.65%、18.90%、11.02%、4.72%和49.31%、16.67%、38.19%、18.75%、25.69%、8.33%。各耐药基因检测阳性率呈逐年升高趋势。结论 2013-2015年高血压上呼吸道感染者鲍曼不动杆菌对头孢类抗生素的耐药明显,耐药基因阳性率逐年升高,耐药基因检测对防控病原菌耐药性发展具有重要意义。
[Abstract]:Objective to study the changes of drug resistance gene and drug resistance of Acinetobacter baumannii in upper respiratory tract infection of patients with hypertension, and to provide guidance for the prevention and control of clinical infectious diseases. Methods the sputum samples of patients with hypertension upper respiratory tract infection were collected. Results 377 strains of Acinetobacter baumannii were isolated from 2013-2015. The resistance rate of each strain to aztreonam, cefepime, cefotaxime and ceftazidime was 100%, respectively. The drug resistance rates of levofloxacin and ampicillin were 77.98% and 77.98%, respectively. The resistance rates to amikacin and imipenem were 35.28% and 34.222.377 strains of Acinetobacter baumannii OXA-23OXA-58TEMERIMP and 22 strains of CTX-M-9, respectively. The positive rate of CTX-M-9 gene of Acinetobacter baumannii OXA-23 OXA-58-TEMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPERIMPER-M-9 was 27.364.72.722.0816.044.772.2832.283.283.283.283.2811.81N and 18.9018.90% and 49.3116.677.38.198.198.1918.750.25.69698.330.Conclusion the positive rate of drug resistance genes in the respiratory tract of the first respiratory tract of 2013-2015 is increasing year by year. The resistance to cephalosporins is obvious. The positive rate of drug resistance genes is increasing year by year. The detection of drug resistance genes is of great significance to the development of drug resistance of pathogenic bacteria.
【作者单位】：黔东南州民族职业技术学院;
【分类号】：R544.1;R56

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