黄芪注射液对常规抗结核化疗药物减毒增效作用的系统评价

发布时间：2018-03-27 06:10

本文选题：肺结核　切入点：黄芪注射液　出处：《山东医药》2017年24期

【摘要】：目的系统评价黄芪注射液对常规抗肺结核化疗药物的减毒增效作用,为黄芪注射液的临床应用提供科学依据。方法计算机检索CBM、CNKI、维普、万方、Pub Med、Embase、ISI、Cochrane Library、中国及美国临床试验注册中心等数据库。应用Cochrane协作网随机对照研究质量评价标准评价纳入研究质量,并对相关数据进行Meta分析。结果纳入22项随机对照研究,肺结核患者2 320例,黄芪注射液联合化疗组(黄芪+化疗组)1 149例、单纯化疗组1 171例。Meta分析结果显示,治疗2~4个月时,黄芪+化疗组痰菌转阴率、病灶吸收改善率、结核空洞缩小率、症状体征改善率均高于单纯化疗组,消化道反应、肝功能损伤、皮疹及视神经炎发生率均低于单纯化疗组(P均0.05);黄芪+化疗组治疗1~2年细菌学复发率低于单纯化疗组(P0.05)。结论黄芪注射液辅助治疗肺结核可提高常规抗结核化疗药物的治疗效果,并可减轻化疗药物的不良反应。
[Abstract]:Objective to evaluate the attenuated and synergistic effect of Huangqi injection on conventional anti-tuberculosis chemotherapy drugs, and to provide scientific basis for clinical application of Astragalus membranaceus injection. Pub Medsite Embase, Iris Cochrane Library, Chinese and American Clinical trial Registry and other databases. The quality evaluation criteria of randomized controlled study with Cochrane collaboration network were used to evaluate the quality of the study, and the relevant data were analyzed by Meta. The results were included in 22 randomized controlled trials. There were 2 320 cases of pulmonary tuberculosis, 1 149 cases of astragalus injection combined chemotherapy group and 1 171 cases of simple chemotherapy group. The results of Meta analysis showed that after 2 ~ 4 months of treatment, the rate of sputum bacteria turning negative and the rate of improvement of focus absorption in astragalus chemotherapy group were improved. The reduction rate of tuberculosis cavity, the improvement rate of symptoms and signs were higher than those of chemotherapy group, digestive tract reaction, liver function injury, The incidence of skin rash and optic neuritis was lower than that of chemotherapy group (P < 0.05), the bacteriological recurrence rate of astragalus chemotherapy group was lower than that of chemotherapy group for 1 ~ 2 years (P 0.05). Conclusion Astragalus injection adjuvant treatment of pulmonary tuberculosis can improve the therapeutic effect of routine anti-tuberculosis chemotherapy drugs. And can alleviate the adverse reaction of chemotherapeutic drugs.
【作者单位】：遵义医学院附属医院;
【基金】：国家自然科学基金资助项目(81360002)
【分类号】：R521

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