慢性阻塞性肺病急性加重合并呼吸衰竭病人早期肠内营养联合胸腺肽a1的疗效观察

发布时间：2018-04-01 15:43

本文选题：慢性阻塞性肺病　切入点：呼吸衰竭　出处：《肠外与肠内营养》2017年06期

【摘要】：目的 :探讨早期肠内营养(EN)联合胸腺肽a1对AECOPD合并呼吸衰竭的疗效。方法 :135例AECOPD病人随机分为试验A组(EN)45例,试验B组(EN+胸腺肽a1)45例,和对照组45例,对照组予常规临床治疗,试验A组在此基础上予瑞能早期肠内营养鼻饲,试验B组在此基础上予瑞能早期肠内营养鼻饲联合皮下胸腺肽a1针,观察三组机械通气时间,检测炎症指标、营养指标以及T细胞亚群。结果 :治疗一周后,试验A组的炎症指标明显低于对照组(P0.05)、营养指标以及T细胞亚群明显高于对照组(P0.05)、机械通气时间较对照组明显缩短(P0.05);而与试验A组相比,试验B组的炎症指标明显降低(P0.05)、营养指标以及T细胞亚群明显升高(P0.05)、机械通气时间明显缩短(P0.05)。结论 :早期肠内营养治疗不仅能缩短AECOPD合并呼吸衰竭病人机械通气时间,而且能改善病人营养状况,降低其炎症指标,增强其免疫功能,进而提高临床疗效,而早期肠内营养联合胸腺肽a1治疗能进一步改善AECOPD合并呼吸衰竭病人的临床疗效。
[Abstract]:Objective: to investigate the effect of early enteral nutrition (en) combined with thymosin a 1 on AECOPD with respiratory failure.Methods one hundred and thirty-five patients with AECOPD were randomly divided into group A (n = 45), group B (n = 45) and control group (n = 45).Group B was given early enteral nutrition combined with subcutaneous thymosin a 1 injection in group B. the mechanical ventilation time, inflammatory index, nutritional index and T cell subgroup were observed in three groups.In group B, the inflammatory index was significantly decreased, the nutritional index and T cell subgroup were significantly increased, and the mechanical ventilation time was shortened significantly.Conclusion: early enteral nutrition therapy can not only shorten the time of mechanical ventilation in patients with AECOPD complicated with respiratory failure, but also improve the nutritional status of patients, reduce their inflammatory indexes, enhance their immune function, and then improve the clinical efficacy.Early enteral nutrition combined with thymosin a 1 therapy can further improve the clinical efficacy of AECOPD patients with respiratory failure.
【作者单位】：浙江省台州市中心医院ICU;
【分类号】：R459.3;R563

【相似文献】