NIPPV治疗AECOPD呼吸衰竭并意识障碍的临床研究

发布时间：2018-04-02 13:34

本文选题：无创正压通气　切入点：慢性阻塞性肺疾病急性加重期　出处：《中国现代药物应用》2016年21期

【摘要】：目的观察慢性阻塞性肺疾病急性加重期(AECOPD)呼吸衰竭并意识障碍患者采用无创正压通气(NIPPV)治疗的临床效果。方法 72例AECOPD呼吸衰竭并意识障碍患者分为A组和B组,各36例。A组采用NIPPV治疗,B组采用常规治疗。分别于治疗前、治疗24 h、治疗72 h时观察两组患者的生理指标情况,观察两组患者治愈率及院内死亡率。结果治疗前,两组患者各项生理指标比较,差异无统计学意义(P0.05)。治疗后,A组患者治愈率88.9%高于B组的52.8%,差异具有统计学意义(P0.05)。A组治疗24 h、治疗72 h时动脉血氧分压(Pa O2)均高于B组,动脉血二氧化碳分压(Pa CO2)及心率(HR)均低于B组,差异具有统计学意义(P0.05)。两组患者呼吸(RR)、院内死亡率比较差异无统计学意义(P0.05)。结论 AECOPD呼吸衰竭并意识障碍患者采用NIPPV治疗时,具有良好的治疗效果,可提升治愈率。
[Abstract]:Objective to observe the clinical effect of noninvasive positive pressure ventilation (NIPPV) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) with respiratory failure and consciousness disorder. Methods 72 patients with AECOPD respiratory failure and consciousness disorder were divided into group A and group B. 36 cases in group A were treated with NIPPV, group B were treated with routine therapy, the physiological indexes, cure rate and hospital mortality were observed at 24 hours before treatment and 72 hours after treatment, respectively. Results before treatment, the cure rate and hospital mortality were observed. After treatment, the cure rate of group A was 88.9% higher than that of group B (52.8%). The difference was statistically significant in group A (24 h) and in group A (72 h). PaCO2) and HR) were lower in group B than those in group B. the difference was statistically significant (P 0.05). There was no significant difference in hospital mortality between the two groups. Conclusion when patients with AECOPD respiratory failure and disturbance of consciousness are treated with NIPPV, there is no significant difference in hospital mortality. It has good therapeutic effect and can improve the cure rate.
【作者单位】：洛阳市新区人民医院呼吸内科;
【分类号】：R563.9;R563.8

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