左氧氟沙星与头孢西丁治疗成人非重症社区获得性肺炎的成本-效果分析

发布时间：2018-04-03 11:23

本文选题：左氧氟沙星　切入点：头孢西丁　出处：《中国药房》2015年29期

【摘要】：目的:评价左氧氟沙星与头孢西丁治疗成人非重症社区获得性肺炎(CAP)的成本-效果。方法:选取71例成人非重症CAP住院患者,按照使用抗菌药物的不同分成左氧氟沙星组(A组)33例和头孢西丁组(B组)38例。A组患者静脉滴注甲磺酸左氧氟沙星注射液200 ml,每日1次;B组患者静脉滴注注射用头孢西丁钠2.0 g,每日3次。疗程均为8 d。观察两组患者的临床疗效、显效时间、不良反应,并进行成本-效果分析。结果:A组和B组患者的总有效率分别为87.88%和65.79%,显效时间分别为(5.53±2.56)d和(3.87±3.03)d,差异均有统计学意义(P0.05);两组患者不良反应发生率比较,差异无统计学意义(χ2=0.47,P0.05)。A组和B组方案的总成本分别为6 748.93元和8 110.34元,成本-效果比分别为76.80和123.28,增量成本-效果比为-61.63%。敏感度分析结果与成本-效果分析结果一致。结论:左氧氟沙星治疗成人非重症CAP更为经济。
[Abstract]:Objective: To evaluate the levofloxacin and cefoxitin in the treatment of adult non severe community-acquired pneumonia (CAP) cost effectiveness. Methods: 71 cases of adult non hospitalized patients with severe CAP, according to the use of antibiotics is divided into levofloxacin group (A group) 33 cases and cefoxitin group (B group) 38 cases in group.A patients with intravenous infusion of Levofloxacin Mesylate Injection 200 ml, 1 times a day; patients in group B intravenous infusion of Cefoxitin Sodium for Injection 2 g, 3 times a day. The treatment course was 8 d. to observe the clinical efficacy of the two groups of patients, onset time, adverse reaction, and the effect analysis. Results: A group and B group of patients with total the efficiency were 87.88% and 65.79% respectively, the time (5.53 + 2.56) D and (3.87 + 3.03) d, the differences were statistically significant (P0.05); two groups of patients with adverse reaction rate comparison, the difference was not statistically significant (2=0.47, P0.05).A group and B group of the total scheme The cost is 6748.93 yuan and 8110.34 yuan respectively, the cost effectiveness ratio is 76.80 and 123.28 respectively, and the incremental cost-effectiveness ratio is -61.63%.. The sensitivity analysis result is consistent with the cost-effectiveness analysis result. Conclusion: levofloxacin is more economical in the treatment of adult non critical CAP.

【作者单位】：德阳市第二人民医院药剂科;
【分类号】：R563.1

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