探讨慢性阻塞性肺疾病继发性骨质疏松的危险因素在维吾尔族男性和汉族男性间的差异

发布时间：2018-04-03 12:57

  本文选题：骨质疏松　切入点：慢性阻塞性肺疾病　出处：《新乡医学院》2017年硕士论文

【摘要】：背景慢性阻塞性肺疾病是一种慢性炎症性肺疾病,易并发包括骨质疏松在内的多种并发症,并发症显著增加致残率,死亡率和加重慢性阻塞性肺疾病的经济负担。其并发的骨质疏松及骨折导致病情恶化,甚至死亡。至今有关慢性阻塞性肺疾病继发性骨质疏松症肯定的危险因素有:吸烟,缺氧,全身炎症反应,糖皮质激素的使用,营养缺乏和高甲状旁腺激素。有学者研究发现不同民族及地域人群部分疾病的患病率发病危险因素存在民族及地域差异。新疆地区慢性阻塞性肺疾病继发性骨质疏松的发病危险因素在维吾尔族和汉族间是否存在差异,亟待研究。目的探索慢性阻塞性肺疾病继发性骨质疏松症的危险因素在维吾尔族男性和汉族男性之间的差异,为新疆慢性阻塞性肺疾病继发性骨质疏松症的预防和控制提供参考。方法选取新疆哈密地区中心医院、哈密红星医院呼吸内科2015年10月至2016年12月住院患者,经询问病史、体格检查及肺功能检查明确诊断为慢性阻塞性肺疾病,且经骨头密度测定仪明确诊断合并骨质疏松的男性患者,共收集107例男性患者,按民族分两组,一组为维吾尔族56例,另一组为汉族51例,两组患者均检测缺氧指标氧分压、全身炎症指标C反应蛋白、甲状旁腺激素水平,称体重及量身高计算体重指数,调查吸烟情况并计算吸烟量,调查年龄及有无使用全身糖皮质激素病史,分别比较两组患者的年龄、氧分压、C反应蛋白、甲状旁腺激素、体重指数、吸烟量及使用全身糖皮质激素史。结果维吾尔族组:年龄为(68.95±6.56)岁,氧分压为(57.89±6.38)mmHg,C反应蛋白为(52.40±59.50)mg/l,甲状旁腺激素为(55.98±35.92)pg/ml,体重指数为(19.21±2.71)kg/m2,吸烟量为(20.73±17.92)包/年;汉族组:年龄为(68.12±7.12)岁,氧分压为(59.21±6.23)mmHg,C反应蛋白为(56.57±51.04)mg/l,甲状旁腺激素水平(39.52±30.31)pg/ml,体重指数为(21.98±3.96)kg/m2,吸烟量为(15.47±14.72)包/年。年龄两组P0.05无统计学差异;甲状旁腺激素、体重指数两个危险因素P0.05,具有统计学差异;氧分压、C反应蛋白和吸烟量三个危险因素P0.05无统计学差异;糖皮质激素使用史,维吾尔族组27例(56例),汉族组28例(51例),χ2值0.29,P0.05无统计学差异。结论新疆地区慢性阻塞性肺疾病继发性骨质疏松的发病危险因素在维吾尔族男性和汉族男性间存在差异;低体重指数和高甲状旁腺激素水平在慢性阻塞性肺疾病继发性骨质疏松中起的作用维吾尔族组大于汉族组。
[Abstract]:Background chronic obstructive pulmonary disease (COPD) is a chronic inflammatory pulmonary disease, which is prone to complications, including osteoporosis, which can significantly increase the rate of disability, mortality and the economic burden of chronic obstructive pulmonary disease (COPD).Its concomitant osteoporosis and fracture cause the condition to worsen, even die.The risk factors associated with COPD secondary osteoporosis are smoking, hypoxia, systemic inflammation, glucocorticoid use, nutritional deficiency and hyperparathyroid hormone.Some scholars have found that there are ethnic and regional differences in the prevalence risk factors of some diseases among different nationalities and regions.The risk factors of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) in Xinjiang area are different between Uygur and Han nationality, which need to be studied urgently.Objective to explore the difference of risk factors of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) between Uygur and Han males, and to provide a reference for the prevention and control of secondary osteoporosis of chronic obstructive pulmonary disease (COPD) in Xinjiang.Methods selected inpatients from October 2015 to December 2016, Department of Respiratory Medicine, Hami Hongxing Hospital, Xinjiang Hami District Central Hospital. The patients were diagnosed as chronic obstructive pulmonary disease by asking for medical history, physical examination and pulmonary function examination.A total of 107 male patients were divided into two groups according to their nationalities: 56 Uygur patients and 51 Han nationality patients. The oxygen partial pressure (oxygen partial pressure) was measured in both groups.Total body inflammation index C-reactive protein, parathyroid hormone level, weight and body height, body mass index, smoking status and smoking volume, age and history of use of systemic glucocorticoid were investigated.Age, oxygen pressure C-reactive protein, parathyroid hormone, body mass index, smoking volume and history of use of glucocorticoid were compared between the two groups.缁撴灉缁村惥灏旀棌缁，

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