雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织的损伤

发布时间：2018-04-03 19:27

本文选题：雾化吸入　切入点：气管滴注　出处：《山东大学学报(医学版)》2017年12期

【摘要】：目的探讨雾化吸入及气管滴入阿米卡星、替加环素对健康小鼠支气管和肺组织损伤的不同。方法将144只昆明种小白鼠随机分为9组(每组16只):空白对照组、生理盐水吸入组、阿米卡星低浓度吸入组、阿米卡星高浓度吸入组、替加环素低浓度吸入组、替加环素高浓度吸入组、生理盐水滴入组、阿米卡星滴入组及替加环素滴入组,各组给予相应处理,取各组小鼠支气管和肺组织两处的病理标本,比较各组小鼠支气管和肺泡损伤程度的不同。结果替加环素高浓度吸入组及阿米卡星高浓度吸入组小鼠的肺损伤程度评分均显著高于空白对照组(P=0.001;P0.001)。阿米卡星高浓度吸入组小鼠的肺损伤程度评分显著高于生理盐水滴入组(P0.001),亦显著高于替加环素滴入组(P=0.001)。结论无论雾化吸入还是气管内滴入均对小鼠肺组织有损伤,而雾化吸入阿米卡星对小鼠肺泡损伤程度高于气管滴入替加环素。
[Abstract]:Objective to investigate the effects of aerosol inhalation and trachea instillation of amikacin and tegicycline on bronchial and lung injury in healthy mice.Methods 144 Kunming mice were randomly divided into 9 groups (16 rats in each group: blank control group, saline inhalation group, amikacin low concentration inhalation group, amikacin high concentration inhalation group, tegacycline low concentration inhalation group).The histopathological specimens of the bronchi and lung tissues of mice were taken from each group, which were treated with tegicycline, saline, amikacin and tegacyclin.The degree of bronchoalveolar injury in each group was compared.Results the score of lung injury in the high dose inhaled group and amikacin inhalation group was significantly higher than that in the blank control group.The lung injury score of the mice in the amikacin inhalation group was significantly higher than that in the saline drip group (P 0.001), and also higher than that in the tigacycline group (P 0.001).Conclusion both inhalation and intratracheal instillation of amikacin can injure the lung tissue of mice, and the degree of injury caused by atomization inhalation of amikacin is higher than that of tigicycline by trachea drip.
【作者单位】：莱芜市人民医院呼吸内科;山东大学齐鲁医院呼吸内科;
【基金】：山东省科学技术发展计划(2012GSF11859)
【分类号】：R56

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