间质性肺疾病急性加重患者九项呼吸道常见病原体检测分析

发布时间：2018-04-04 09:56

本文选题：间质性肺疾病急性加重　切入点：病因　出处：《实用医学杂志》2017年06期

【摘要】：目的:探讨九项呼吸道病原体(以下简称:九联检)在间质性肺疾病急性加重(AE-ILD)中的作用,为AE-ILD发病机理的研究,以及有效诊治方案的探讨提供依据。方法:检测AE-ILD、ILD稳定期患者及正常人血清九联检Ig M抗体的表达情况;观察其动态变化。结果:73例AE-ILD组、72例ILD稳定期组及50例正常对照组机体九种病原体总体阳性率分别为52.1%、27.8%、22.0%,AE-ILD组分别与ILD稳定期组和正常对照组比较,病原体总体阳性率差异均有统计学意义(P=0.003;P=0.001),而ILD稳定期组与正常对照组比较差异无统计学意义(P=0.417)。上述三组病毒总体阳性率分别为31.5%、16.7%、10.0%,其中AE-ILD组分别与ILD稳定期组、正常对照组比较差异有统计学意义(P=0.037;P=0.005),三组病例中以支原体、乙型流感病毒、呼吸道合胞病毒的阳性率较高。动态观察九联检Ig M抗体变化结果显示随入院时间的延长,AE-ILD患者九联检病原体阳性数逐渐下降。结论:AE-ILD患者九项呼吸道病原体感染率高于ILD稳定期及正常对照组,提示间质性肺疾病患者病情的急性加重可能与感染诱发有关。
[Abstract]:Objective: to investigate the role of nine respiratory pathogens in acute exacerbation of interstitial pulmonary disease (AE-ILD), and to provide evidence for the study of pathogenesis of AE-ILD and effective treatment.Methods: to detect the expression and dynamic changes of serum nine jiu IgM antibody in patients with AE-ILD ILD and normal subjects.Results the total positive rates of nine pathogens in 72 cases of stable ILD group and 50 cases of normal control group were 52.1% and 27.827.822.0% in AE-ILD group, respectively, compared with ILD stable period group and normal control group.There were significant differences in the total positive rates of pathogens between the two groups, but there was no significant difference between the ILD stable group and the normal control group.The total positive rates of the three groups were 31. 5% and 16. 710%, respectively. The positive rates of AE-ILD group and ILD stable group were significantly higher than those of normal control group. The positive rates of mycoplasma, influenza B virus and respiratory syncytial virus were higher in the three groups.The results of dynamic observation showed that the positive number of nine-joint detection pathogens in patients with AE-ILD decreased gradually with the prolongation of admission time.Conclusion the infection rate of 9 respiratory pathogens in the patients with wor-AE-ILD is higher than that in the stable stage of ILD and the normal control group, suggesting that the acute exacerbation of the condition of the patients with interstitial lung disease may be related to the induction of infection.
【作者单位】：浙江中医药大学附属第二医院呼吸内科;
【基金】：国家自然科学基金(编号:30971323)
【分类号】：R563.9

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