慢性阻塞性肺疾病急性加重期患者血清GRO-α、MRpro-ADM水平变化及临床意义

发布时间：2018-04-09 00:23

本文选题：急性加重期慢性阻塞性肺疾病　切入点：生长调节致癌基因-α　出处：《山东医药》2017年38期

【摘要】：目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者血清生长调节致癌基因-α(GRO-α)、肾上腺髓质素前体中段肽(MRpro-ADM)的水平变化,并探讨其临床意义。方法选取79例AECOPD患者为AECOPD组,并于同期随机选取60例稳定期COPD患者为稳定期COPD组、60例健康体检者为对照组。采用酶联免疫吸附法测定各组血清GRO-α水平,时间分辨免疫荧光法测定各组血清MRpro-ADM水平,同时测定各组第一秒用力呼气容积(FEV1)、用力肺活量(FVC),计算FEV1/FVC。血清GRO-α、MRpro-ADM与肺功能指标FEV1、FVC、FEV1/FVC的相关性采用Pearson相关分析;绘制受试者工作特征曲线(ROC曲线)分析血清GRO-α、MRpro-ADM预测AECOPD的诊断价值。结果与对照组相比,AECOPD组、稳定期COPD组血清GRO-α、MRpro-ADM水平高,且AECOPD组较稳定期COPD组高(P均0.05)。与对照组相比,AECOPD组、稳定期COPD组FEV1、FVC、FEV1/FVC低,且AECOPD组较稳定期COPD组低(P均0.05)。血清GRO-α水平与FEV1、FVC、FEV1/FVC均呈负相关关系(r分别为-0.471、-0.509、-0.511,P均0.05);血清MRpro-ADM与FEV1、FVC、FEV1/FVC均呈负相关关系(r分别为-0.539、-0.517、-0.498,P均0.05)。血清GRO-α预测AECOPD的ROC曲线下面积为0.854,最佳截断值为109.34 ng/L,此时灵敏度、特异度分别为0.82、0.91,准确性为0.83;血清MRpro-ADM预测AECOPD的ROC曲线下面积为0.808,最佳截断值为1.28 nmol/L,此时灵敏度、特异度分别为0.75、0.82,准确性为0.77。结论AECOPD患者血清GRO-α、MRpro-ADM水平升高,早期检测可作为辅助诊断AECOPD的重要生物学标志物。
[Abstract]:Objective to observe the changes of serum growth regulation oncogene-伪-GRO- 伪 and MRpro-ADM in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD), and to explore its clinical significance.Methods Seventy-nine patients with AECOPD were selected as AECOPD group and 60 patients with stable COPD as control group.Serum GRO- 伪 levels were measured by enzyme-linked immunosorbent assay (Elisa), serum MRpro-ADM levels were measured by time-resolved immunofluorescence assay, and FEV1, FEV1, FEV1, FEV1 / FVC were measured.The correlation between serum GRO- 伪 -MRpro-ADM and the pulmonary function index FEV1 / FV1 / FVC was analyzed by Pearson correlation analysis, and the diagnostic value of serum GRO- 伪 MRpro-ADM in predicting AECOPD was analyzed.Results compared with the control group, the serum levels of GRO- 伪 -MRpro-ADM in the stable COPD group were higher than those in the control group, and the levels of serum GRO- 伪 -MRpro-ADM in the AECOPD group were higher than those in the stable COPD group (P 0.05).Compared with the control group, FEV1 / FVC1 / FVC of stable COPD group was lower than that of control group, and the FEV1 / FVC of AECOPD group was lower than that of stable COPD group (P 0.05).The area under the ROC curve of serum GRO- 伪 predictive AECOPD is 0.854, the best truncation value is 109.34 ng / L, the sensitivity and specificity are 0.82n0.91 and the accuracy is 0.83.The area under the ROC curve of serum MRpro-ADM for AECOPD prediction is 0.808, the best truncation value is 1.28 nmolL / L, the sensitivity is 0.28 nmol / L, respectively.The specificity and accuracy were 0.75 and 0.82, respectively.Conclusion Serum GRO- 伪 -MRpro-ADM level in patients with AECOPD is increased, and early detection can be used as an important biomarker in the diagnosis of AECOPD.
【作者单位】：武汉市中心医院;
【基金】：湖北省自然科学基金资助项目(2016CFB378)
【分类号】：R563.9

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