益气活血化痰方联合小剂量阿托伐他汀对高危性COPD患者动脉僵硬度、血液黏度及预后的影响研究

发布时间：2018-04-10 02:17

本文选题：益气活血化痰方　切入点：阿托伐他汀　出处：《重庆医学》2017年28期

【摘要】：目的探讨益气活血化痰方联合小剂量阿托伐他汀对高危性慢性阻塞性肺疾病(COPD)患者动脉僵硬度、血液黏度及预后的影响。方法随机数字表法将240例存在心血管病变危险因素的高危性COPD患者分成他汀组(A组)、益气活血化痰组(B组)、联合组(C组)和对照组(D组),每组60例。4组均予以常规治疗方案,A组联合小剂量阿托伐他汀,B组联合益气活血化痰方,C组在A组基础上联合益气活血化痰方,均持续治疗6个月。观察4组治疗前后中医证候积分、动脉僵硬度指标及血液流变学指标变化差异,记录其不良反应发生情况及预后情况。结果治疗6个月后,4组患者中医证候积分及颈动脉-股动脉脉搏波传导速度(PWV)水平均较治疗前明显降低,且C组、A组、B组、D组逐渐升高(P0.05)。治疗6个月后,除D组患者全血黏度、红细胞压积未见明显改变(P0.05),其余3组患者均较治疗前明显降低,C组明显低于A组和B组(P0.05),A组和B组比较差异无统计学意义(P0.05)。4组患者不良反应发生率比较差异无统计学意义(P0.05),C组、A组、B组、D组患者BODE指数逐渐升高(P0.05)。结论益气活血化痰方联合小剂量阿托伐他汀对调节有心血管病变危险因素的高危性COPD患者血液流变学状态、促进患者预后恢复等具有积极作用。
[Abstract]:Objective to investigate the Yiqi Huoxue Huatan Decoction Combined with small dose of atorvastatin on high risk of chronic obstructive pulmonary disease (COPD) patients with arterial stiffness, affecting blood viscosity and prognosis. Methods randomly 240 cases of cardiovascular disease and risk factors of high-risk COPD patients were divided into atorvastatin group (A group), Guanxinping group (B group), combination group (C group) and control group (D group), each group of 60 cases of.4 group were given conventional treatment, A group combined with low-dose atorvastatin, B group combined with Yiqi Huoxue Huatan recipe group, C in A were based on the combination of vital qi blood phlegm, continued 6 months of treatment. The 4 groups were observed before and after treatment of TCM syndrome integral, index difference of arterial stiffness index and blood rheology, record the occurrence of adverse reactions and prognosis. Results 6 months after treatment, 4 groups of patients with TCM syndrome score and carotid femoral pulse wave conduction Speed (PWV) levels were significantly lower than that before treatment, and C group, A group, B group, D group increased (P0.05). After 6 months of treatment, patients in D group blood viscosity, hematocrit did not change significantly (P0.05), the other 3 groups of patients were significantly lower than that before treatment, C group was significantly lower than that of A group and B group (P0.05), there was no significant difference between A group and B group (P0.05).4 groups of patients with adverse reaction rate had no significant difference (P0.05), C group, A group, B group, BODE index in patients with D group increased (P0.05). Conclusion Yiqi Huoxue Huatan recipe combined with small dose of atorvastatin with cardiovascular disease risk factors on the regulation of high-risk COPD patients blood rheology, promote the prognosis of recovery has a positive effect.

【作者单位】：新疆医科大学第一附属医院中医内科;
【分类号】：R563.9

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