骨桥蛋白与肺部疾病关系的研究进展

发布时间：2018-04-10 20:15

  本文选题：糖基化蛋白 + 骨基质蛋白　； 参考：《中国呼吸与危重监护杂志》2017年05期

【摘要】：正骨桥蛋白(osteopontin,OPN)是一种糖基化蛋白,广泛存在于细胞外基质中。最初认为OPN是一种重要的骨基质蛋白,与骨的形成和发展密切相关。但近年来发现OPN在各种组织中均有表达,如骨、肾、肺、肝、膀胱、乳腺、睾丸、脑、胰腺等~([1])。同时,OPN在多种细胞类型中也有表达,如骨细胞、神经细胞、上皮细胞、内皮细胞、血管平滑肌细胞、活化的T淋巴细胞、巨噬细胞等~([2])。越来越多证据表明OPN参与了肺部疾病的病理过程,本文将就OPN与部分肺部疾病的研究进展作一综述,为这些疾病的诊治提供新思路。
[Abstract]:Osteopontin (OPN) is a glycosylated protein widely found in extracellular matrix.OPN was initially considered to be an important bone matrix protein closely related to bone formation and development.However, in recent years, it has been found that OPN is expressed in various tissues, such as bone, kidney, lung, liver, bladder, mammary gland, testis, brain, pancreas and so on.At the same time, OPN is also expressed in many cell types, such as bone cells, nerve cells, epithelial cells, endothelial cells, vascular smooth muscle cells, activated T lymphocytes, macrophages and so on.More and more evidences show that OPN is involved in the pathological process of pulmonary diseases. This article will review the research progress of OPN and some pulmonary diseases, and provide new ideas for the diagnosis and treatment of these diseases.
【作者单位】： 西南医科大学附属医院呼吸一科;
【分类号】：R563
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本文编号：1732742