吸入糖皮质激素联合茶碱与联合长效β2受体激动剂治疗哮喘的效果比较

发布时间：2018-04-13 12:02

本文选题：糖皮质激素 + 茶碱　；参考：《深圳中西医结合杂志》2017年19期

【摘要】：目的:比较吸入糖皮质激素联合茶碱与联合长效β2受体激动剂(LABA)在哮喘治疗中的临床效果。方法:选取2013年1月至2016年5月佛山市南海区第七人民医院收治且确诊的60例支气管哮喘患者作为研究对象,随机分为观察组和对照组各30例。对照组给予糖皮质激素联合长效β2受体激动剂治疗,观察组给予糖皮质激素联合茶碱治疗。对比两组的肺功能指标及临床疗效。结果:两组治疗前1s用力呼出量/用力肺活量比值(FEV1)、用力呼气峰流速(PEF)、肺活量(VC)及用力肺活量(FVC)比较,差异均无统计学意义(P0.05);治疗后观察组上述各项指标改善情况均优于对照组,差异具有统计学意义(P0.05)。观察组治疗总有效率为93.3%,对照组为73.3%,观察组治疗有效率高于对照组,差异具有统计学意义(P0.05)。结论:糖皮质激素联合茶碱治疗哮喘,可有效舒张支气管平滑肌,拮抗气道炎症,改善通气功能,促进肺功能的恢复,可作为首选哮喘治疗方案在临床应用。
[Abstract]:Aim: to compare the clinical effects of inhaled glucocorticoid combined with theophylline and long acting 尾 2 receptor agonist Laba in the treatment of asthma.Methods: from January 2013 to May 2016, 60 patients with bronchial asthma treated in the Seventh people's Hospital of Nanhai District, Foshan City, were selected as the study objects. The patients were randomly divided into two groups: the observation group (n = 30) and the control group (n = 30).The control group was treated with glucocorticoid combined with long-acting 尾 _ 2 agonist, the observation group was treated with glucocorticoid combined with theophylline.Pulmonary function index and clinical effect were compared between the two groups.Results: the forced exhalation / forced vital capacity ratio (FEV1), forced expiratory peak flow rate (PEFV), vital capacity (VC) and forced vital capacity (FVC) were compared between the two groups before treatment.After treatment, the improvement of the above indexes in the observation group was better than that in the control group, and the difference was statistically significant.The total effective rate of treatment was 93.3g in the observation group and 73.3 in the control group. The effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P 0.05).Conclusion: glucocorticoid combined with theophylline can effectively dilate bronchial smooth muscle, antagonize airway inflammation, improve ventilation function and promote the recovery of lung function.
【作者单位】：佛山市南海区第七人民医院;
【分类号】：R562.25

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