生活环境中主要空气污染物浓度与哮喘患者肺功能、呼出气一氧化氮和血清IgE水平的关系

发布时间：2018-04-14 05:01

本文选题：哮喘 + 主要空气污染物　；参考：《山东医药》2017年11期

【摘要】：目的探讨生活环境中主要空气污染物浓度与哮喘患者肺功能、呼出气一氧化氮(FeNO)和血清IgE水平的相关性。方法选择95例复诊的成人哮喘患者,检测其肺功能[包括用力肺活量(FVC)、第一秒用力肺活量(FEV1)、FEV1/FVC、呼气流量峰值(PEF)、最大呼气中期流量(MMEF)]、Fe NO和血清IgE。收集患者复诊前第1、2、3 d及1个月生活环境中空气主要污染物浓度数据[包括包括PM_(2.5)、PM_(10)、二氧化硫(SO_2)、一氧化碳(CO)、二氧化氮(NO_2)、臭氧(O_3)]。采用多元线性回归法分析患者复诊前第1、2、3天及1个月生活环境中主要空气污染物浓度与肺功能、Fe NO和血清IgE的相关性。结果 FVC与PM_(2.5)(pre1D)呈负相关(回归系数b为-0.29,P0.05),FEV1与NO_2(pre2D)呈负相关(回归系数b为-0.012,P0.05),PEF与CO(pre1D)、NO_2(pre1D)、O_3(pre1D)、SO_2(pre2D)、CO(pre2D)、NO_2(pre2D)、CO(pre1M)、NO_2(pre1M)呈负相关(回归系数b分别为-0.061,-0.038,-0.013,-0.014,-0.052,-0.053,-0.073,-0.091,P均0.05),Fe NO与O_3(pre2D)、O_3(pre3D)呈正相关(回归系数b分别为0.390,0.379,P均0.05)。结论生活环境PM_(2.5)、SO_2、CO、NO_2、O_3浓度对哮喘患者肺功能有短期影响,O_3对Fe NO有短期影响。PM10浓度与哮喘患者肺功能、Fe NO和血清IgE无相关性。生活环境主要空气污染物浓度与哮喘患者血清IgE无相关性。
[Abstract]:Objective to investigate the main air pollutants in the living environment and the concentration of lung function in asthma, exhaled nitric oxide (FeNO) and the correlation between the level of serum IgE. Methods 95 cases of adult patients with asthma were detected, the pulmonary function including forced vital capacity (FVC), the first second with vital capacity (FEV1), FEV1/FVC, peak expiratory flow (PEF), maximal mid expiratory flow (MMEF), Fe NO and IgE. in serum were collected before the main air pollutants were 1,2,3 and D were 1 months of living environment including concentration data including PM_ (2.5), PM_ (10), sulfur dioxide (SO_2), carbon monoxide (CO), nitrogen dioxide (NO_2), ozone (O_3). Using the method of multiple linear regression analysis of the main air pollutants in patients with 1,2,3 before referral days and 1 months in the living environment and concentration of lung function, the correlation between Fe NO and IgE in serum. Results of FVC and PM_ (2.5) (pre1D) was negatively correlated (regression coefficient B is -0.29, P0. 05, FEV1) and NO_2 (pre2D) showed a negative correlation (regression coefficient B is -0.012, P0.05, PEF) and CO (pre1D), NO_2 (pre1D), O_3 (pre1D), SO_2 (pre2D), CO (pre2D), NO_2 (pre2D), CO (pre1M), NO_2 (pre1M) is negative correlation (regression coefficient b = -0.061, -0.038, -0.013, -0.014, -0.052, -0.053, -0.073, -0.091, P 0.05), Fe NO and O_3 (pre2D), O_3 (pre3D) positive correlation (regression coefficient b = 0.390,0.379, P < 0.05). Conclusion the living environment of PM_ (2.5). SO_2, CO, NO_2, O_3 concentration has a short-term effect on lung function in asthma, O_3 has the effect of concentration of.PM10 and pulmonary function in asthma in the short term there is no relationship between Fe NO Fe NO, and serum IgE. No correlation between the living environment of major air pollutants concentration and serum IgE of asthmatic patients.

【作者单位】：河北医科大学第二医院;
【分类号】：R562.25

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