呼吸机依赖患者痰液中SP-A与动脉血氧合指数变化的研究

发布时间：2018-04-14 09:16

本文选题：肺表面活性物质相关蛋白A + 血气分析　；参考：《重庆医学》2014年20期

【摘要】：目的测定呼吸机依赖患者痰液中肺表面活性物质相关蛋白-A(SP-A)的表达,研究SP-A与氧合指数及动脉血氧分压水平的变化。方法将机械通气患者分为呼吸机依赖组(A组)和顺利脱机组(B组),收集患者上呼吸机不同阶段上机当天及上机后2、7d的痰液标本,应用ELISA检测两组患者痰液上清液中SP-A水平和相应时段的动脉氧分压。结果上机当天A组SP-A水平、氧合指数、动脉氧分压低于B组(P0.05);A组上机2d痰液中SP-A水平低于上机当天,上机7d低于上机2d,差异有统计学意义(P0.05);A组上机2d氧合指数及氧分压高于上机当天(P0.05),上机后7d氧合指数、氧分压与上机后2d比较差异无统计学意义(P0.05)。结论通过检测痰液中SP-A水平可早期判断呼吸机依赖或呼吸机相关性肺损伤的发生,可提供新的治疗途径及思路。
[Abstract]:Objective to determine the ventilator dependent sputum in patients with pulmonary surfactant associated protein -A (SP-A) expression changes of SP-A and oxygenation index and PaO2 level. Methods the mechanical ventilation were divided into ventilator dependent group (A group) and the successful weaning group (B group), 2,7d day and sputum machine collect the patient ventilator in different stages on the application of ELISA SP-A detection, arterial oxygen level and the corresponding period of two groups of patients with sputum supernatant in partial pressure. The results on the day of A group SP-A, oxygenation index, arterial oxygen pressure lower than that of B group (P0.05); A group on the 2D level of SP-A was lower than that in the sputum on the computer the 7d is lower than 2D, the difference was statistically significant (P0.05); A group on 2D oxygenation index and oxygen partial pressure is higher than that on the day (P0.05), 7d, oxygenation index machine, oxygen partial pressure and on 2D had no significant difference (P0.05) conclusion. The level of SP-A in sputum can be used to determine the incidence of ventilator dependence or ventilator-associated lung injury in early stage, and can provide a new way of treatment and ideas.

【作者单位】：重庆市中医院重症医学科;
【基金】：重庆市卫生局科研项目(2010-2-240)
【分类号】：R563.8

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