前列地尔对慢性阻塞性肺疾病急性加重期患者血浆N端B型脑钠肽及肺动脉压的影响

发布时间：2018-04-18 03:19

本文选题：慢性阻塞性肺疾病 + N端B型脑钠肽　；参考：《广东医学》2014年14期

【摘要】：目的观察前列地尔对慢性阻塞性肺疾病(COPD)急性加重期患者血浆N端B型脑钠肽(NTproBNP)及肺动脉压的影响。方法将42例COPD急性加重期患者,分为观察组22例及对照组20例,两组均给予常规治疗。观察组在常规治疗基础上静脉注射前列地尔10μg,2次/d,2周为一疗程。观察两组患者NTproBNP、肺动脉压、Tei指数、PaO2、PaCO2、FEV1/预计值及FEV1/FVC的变化以及不良事件的发生情况。结果治疗后,两组患者NT-proBNP、肺动脉压及Tei指数均下降,观察组下降更为明显,差异有统计学意义(P0.05),而在PaO2、FEV1/预计值及FEV1/FVC升高,PaCO2下降方面,观察组也均优于对照组,差异有统计学意义(P0.05),同时观察组不良事件较少。结论前列地尔治疗COPD急性加重期及肺动脉高压安全有效。
[Abstract]:Objective to observe the effect of alprostadil on plasma N-terminal brain natriuretic peptide NTproBNPs and pulmonary artery pressure in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD).Methods 42 patients with acute exacerbation of COPD were divided into observation group (n = 22) and control group (n = 20).In the observation group, alprostadil 10 渭 g / d was injected intravenously on the basis of routine therapy for 2 weeks as a course of treatment.The changes of FEV1 / FEV1/FVC and the occurrence of adverse events were observed in two groups of patients, including NTproBNPs, Tei index of pulmonary artery pressure and Paco _ 2 Paco _ 2 / FEV1 / predicted values.Results after treatment, the NT-proBNP, pulmonary artery pressure and Tei index in the two groups were all decreased, especially in the observation group, the difference was significant (P 0.05). The observation group was also superior to the control group in terms of the predicted value of Pao _ 2, FEV _ 1 / and the increase of FEV1/FVC and the decrease of Paco _ 2.The difference was statistically significant (P 0.05), and the adverse events in the observation group were less.Conclusion alprostadil is safe and effective in the treatment of acute exacerbation of COPD and pulmonary hypertension.
【作者单位】：山东省德州市人民医院内二科;山东省德州市人民医院心研室;
【分类号】：R563.9

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