中性粒细胞CD64指数在预测慢性阻塞性肺疾病急性加重期患者预后中的临床价值

发布时间：2018-04-21 06:09

本文选题：中性粒细胞CD指数 + 慢性阻塞性肺疾病急性加重期　；参考：《现代预防医学》2017年19期

【摘要】：目的探讨中性粒细胞CD64指数预测慢性阻塞性肺疾病急性加重期(AECOPD)患者预后的临床价值。方法采用前瞻性研究,共纳入AECOPD患者71例。根据预后,患者分为两组:死亡组21例,好转组50例。所有患者在入院当天、第3天和第7天检测中性粒细胞CD64指数和降钙素原(PCT),比较其在两组之间的动态变化。结果入院当天和第3天中性粒细胞CD64指数和PCT在两组之间差异均无统计学意义(P0.05),而第7天测量结果在两组之间差异均有统计学意义(P0.05),中性粒细胞CD64指数比值和PCT比值在两组之间差异均有统计学意义(P0.05)。绘制预测AECOPD患者的受试者工作特征(ROC)曲线,中性粒细胞CD64指数比值、第7天中性粒细胞CD64指数、PCT比值和第7天PCT的曲线下面积(AUC)分别为:0.866、0.818、0.836和0.796,最佳截取值分别为:0.376、1.37、0.356和1.03,敏感度和特异度分别为:85.7%和82.0%、76.2%和74.0%、81.0%和80.0%、71.4%和76.0%。结论中性粒细胞CD64指数比值能良好预测AECOPD患者住院死亡预后,其价值优于PCT。
[Abstract]:Objective to investigate the clinical value of neutrophil CD64 index in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A prospective study was conducted in 71 patients with AECOPD. According to the prognosis, the patients were divided into two groups: death group (n = 21) and improvement group (n = 50). The neutrophil CD64 index and procalcitonin CD64 index were measured on the day of admission, day 3 and day 7, and the dynamic changes were compared between the two groups. Results there was no significant difference in neutrophil CD64 index and PCT between the two groups on the day of admission and the third day after admission, but on the 7th day there were significant differences between the two groups in the ratio of neutrophil CD64 index and PCT. There was significant difference in the ratio between the two groups (P 0.05). In order to predict the operating characteristics of subjects with AECOPD, the curve of roc and the ratio of neutrophil CD64 index to neutrophil were plotted. On the 7th day, the ratio of neutrophil CD64 index and the area under the curve of PCT on the 7th day were: 1: 0.866 / 0.8180.836 and 0.796, respectively. The optimum cut-off values were: 0.3761.37 / 0.356 and 1.03.The sensitivity and specificity were 85.7% and 82.076.2% and 74.081.0% and 80.071.4% and 76.0%, respectively. Conclusion the ratio of neutrophil CD64 index can predict the prognosis of AECOPD patients, and its value is superior to that of AECOPD.
【作者单位】：南通市第二人民医院呼吸内科;
【基金】：2013年度南通市市级科技计划基金项目(HS13913) 2014年度青年医学人才科研基金项目(WQ2014028)
【分类号】：R563.9

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