晚期肺癌患者化疗后肺部感染的病原菌分布和对免疫功能的影响研究

发布时间：2018-04-22 16:30

本文选题：肺癌 + 化疗　；参考：《中华医院感染学杂志》2017年22期

【摘要】：目的分析晚期肺癌化疗后肺部感染的病原菌分布及对免疫功能的影响研究。方法分析2015年1月-2017年1月医院接受化疗的118例晚期肺癌患者的临床资料,依据化疗后是否并发肺部感染分为感染组58例及对照组60例,采用美国赛默飞微生物全自动鉴定仪进行病原菌鉴定分型,对比两组患者T细胞亚群及外周血免疫球蛋白等免疫功能指标。结果感染组58例患者共分离病原菌80株,其中革兰阴性菌55株占68.75%,革兰阳性菌21株占26.25%,真菌4株占5.00%;感染组患者CD3+T细胞、CD_4~+T细胞、CD_8~+T淋巴细胞及CD_4~+/CD_8~+均显著低于对照组(P0.05);感染组患者外周血IgA、IgG及IgM水平均显著低于对照组,以上差异均有统计学意义(P0.05)。结论晚期肺癌患者化疗后肺部感染主要以革兰阴性菌为主,感染可加剧患者免疫功能异常。
[Abstract]:Objective to analyze the distribution of pathogenic bacteria and its influence on immune function in patients with advanced lung cancer after chemotherapy. Methods the clinical data of 118 patients with advanced lung cancer who received chemotherapy in hospital from January 2015 to January 2017 were analyzed. According to whether the patients were complicated with pulmonary infection after chemotherapy, 58 cases were divided into two groups: 58 cases in the infection group and 60 cases in the control group. The pathogens were identified and typed by the Semofeld Microbe automatic Identification instrument in USA. The T cell subsets and immunoglobulin in peripheral blood of the two groups were compared between the two groups. Results A total of 80 strains of pathogenic bacteria were isolated from 58 patients in the infected group. 55 Gram-negative bacteria accounted for 68.75um, 21 Gram-positive bacteria accounted for 26.25 and 4 fungi accounted for 5.00.The levels of CD3 T cell CD4T lymphocytes and CD4- / CD8T cells in infected patients were significantly lower than those in control group, and the levels of IgAG and IgM in peripheral blood of infected patients were significantly lower than those of control group. They were significantly lower than those in the control group. All the above differences were statistically significant (P 0.05). Conclusion Gram-negative bacteria are the main infection in patients with advanced lung cancer after chemotherapy, and the infection can aggravate the abnormal immune function of the patients.
【作者单位】：赣州市肿瘤医院检验科;赣州市肿瘤医院内一科;
【基金】：江西省自然科学基金资助项目(20142BAB205053)
【分类号】：R563.1;R730.43;R734.2

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