不同肥胖程度的阻塞性睡眠呼吸暂停低通气综合征患者血浆神经肽Y的相关性研究

发布时间：2018-04-23 02:24

本文选题：阻塞性睡眠呼吸暂停低通气综合症 + 体重指数　；参考：《蚌埠医学院》2013年硕士论文

【摘要】：目的：通过检测患者血浆神经肽Y的蛋白水平，揭示其与肥胖的关系，及其对OSAHS发病的影响。方法： 1、选择2011年6月至2012年8月在蚌埠医学院第一附属医院呼吸内科睡眠治疗中心接受多导睡眠图（PSG）检测的患者140例，其中男85例，女55例，年龄范围在50～60岁，平均年龄是53.56±0.71，通过生化检查及详细询问病史排除内分泌代谢性疾病、肝肾功能不全、心血管疾病、脑血管疾病、恶性肿瘤、神经精神系统疾病、风湿性疾病、严重的慢性阻塞性肺疾病作为受试对象。 2、根据不同AHI水平将140例入选者分为四组：非0SAHS35人；轻度OSAHS35人；中度OSAHS34人；重度OSAHS36人。 3、按照不同体重指数（BMI）将140例入选者分为五组：正常体重25人；轻度肥胖37人；中度肥胖29人；重度肥胖19人；过重12人。 4、所有入选者均接受一夜至少7小时的PSG监测记录呼吸紊乱指数（AHI）、最低血氧饱和度（LSaO2），同时测量身高（cm）、体重（kg）、腰围（cm），臀围（cm），并留取静脉血进行神经肽Y测定。结果： 1、不同AHI水平的OSAHS患者，各组间神经肽Y有统计学差异（P＜0.01）；神经肽Y与AHI无直线相关关系，总体相关系数为0.906，呈正相关关系，即OSAHS程度越严重神经肽Y水平越高；神经肽Y与LSaO2无直线相关关系，总体相关系数为-0.939，呈负相关关系，，即OSAHS程度越严重，LSaO2水平越低，神经肽Y越高。 2、不同BMI水平的的患者，各组间神经肽Y有统计学差异（P0.01）；神经肽Y与BMI无直线相关关系，总体相关系数为0.740，呈正相关关系，即肥胖程度越严重，神经肽Y水平越高；通过非参数检验，发现正常体重与肥胖组之间的腰臀比有统计学差异（P＜0.01），神经肽Y与腰臀比的相关系数为0.171，呈正相关关系，即神经肽Y水平随着腰臀比的增大而增高。 3、神经肽Y与AHI、BMI三者之间的关系可有二重线性回归方程NPY=5.091+0.437BMI+0.651AHI表示。结论： OSAHS患者的神经肽Y水平与OSAHS严重程度有关，且随着OSAHS严重程度加重而增加；神经肽Y与肥胖、腰臀比有关，且随着肥胖程度加重、腰臀比增大而增加。
[Abstract]:Objective: The relationship between neuropeptide Y (NPY) and obesity and its effect on the pathogenesis of OSAHS were studied. Methods: 1. From June 2011 to August 2012, 140 patients (85 males and 55 females, aged 50 or 60 years) who were examined by polysomnography (PSG) in the sleep treatment center of Department of Apnea, first affiliated Hospital of Bengbu Medical College, were selected. The average age was 53.56 卤0.71. Endocrine metabolic diseases, liver and kidney dysfunction, cardiovascular diseases, cerebrovascular diseases, malignant tumors, neuropsychiatric diseases, rheumatic diseases were excluded by biochemical examination and detailed inquiry. Severe chronic obstructive pulmonary disease (COPD) was studied. 2. According to different levels of AHI, 140 patients were divided into four groups: non 0SAHS35, mild OSAHS35, moderate OSAHS34 and severe OSAHS36. 3. According to different body mass index (BMI), 140 patients were divided into five groups: normal weight 25, mild obesity 37, moderate obesity 29, severe obesity 19, overweight 12. 4. All the participants were monitored by PSG for at least 7 hours a night to record the respiratory disorder index (AHI) and the lowest oxygen saturation (LSAO _ 2). At the same time, the body height, body weight, waist circumference, hip circumference and neuropeptide Y were measured at the same time. Results: 1. There was significant difference in neuropeptide Y between OSAHS patients with different AHI levels (P < 0.01), and there was no linear correlation between neuropeptide Y and AHI, the overall correlation coefficient was 0.906, which was positive correlation, that is, the more serious the OSAHS, the higher the neuropeptide Y level. There was no linear correlation between neuropeptide Y and LSaO2, and the overall correlation coefficient was -0.939. There was a negative correlation between neuropeptide Y and neuropeptide Y, that is, the more serious the level of OSAHS, the lower the level of LSaO2, the higher the neuropeptide Y. 2in patients with different levels of BMI, there was significant difference in neuropeptide Y between groups (P 0.01), and there was no linear correlation between neuropeptide Y and BMI, the overall correlation coefficient was 0.740, which was positive correlation, that is, the more severe the obesity, the higher the level of neuropeptide Y; The non-parametric test showed that there were significant differences in the WHR between normal body weight and obesity group (P < 0.01), and the correlation coefficient between neuropeptide Y and WHR was 0.171, which indicated that the level of neuropeptide Y increased with the increase of waist-to-hip ratio. 3. The relationship between neuropeptide Y and AHI 0.437BMI 0.651AHI can be expressed by the double linear regression equation NPY=5.091 0.437BMI 0.651AHI. Conclusion: The level of neuropeptide Y in OSAHS patients was related to the severity of OSAHS and increased with the severity of OSAHS, and neuropeptide Y was related to obesity and waist-hip ratio.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R563.9

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