吸烟对COPD稳定期患者血清IL-6、IL-18、CC16水平及营养状况的影响

发布时间：2018-04-24 22:11

  本文选题：慢性阻塞性肺疾病 + 稳定期　； 参考：《山东医药》2017年25期

【摘要】：目的探讨吸烟对慢性阻塞性肺疾病(COPD)稳定期患者血清IL-6、IL-18、Clara细胞分泌蛋白(CC16)水平及营养状况的影响。方法收集COPD稳定期患者200例(COPD组)和同期体检健康者100例(对照组)的病史资料、微型营养评定(MNA)结果并对所有受试者行肺功能检查;用酶联免疫吸附试验(ELISA)检测受试者血清IL-6、IL-18、CC16水平。根据受试者的吸烟史,选取COPD组中吸烟者作为COPD吸烟亚组;对照组中吸烟者作为正常吸烟亚组,未吸烟者作为正常未吸烟亚组。在COPD吸烟亚组中根据吸烟指数(SI)进一步分为SI400亚组与SI≥400亚组,对吸烟COPD稳定期患者的SI、MNA值与血清IL-6、IL-18、CC16进行Spearman相关性分析。结果COPD组与对照组受试者性别构成比、年龄、吸烟指数等差异无统计学意义(P均0.05);COPD组第1秒用力呼气容积(FEV_1)、FEV_1占用力肺活量的百分比(FEV_1/FVC)%、CC16浓度、MNA值均低于对照组,而血清IL-6、IL-18水平均高于对照组,P均0.01。与正常未吸烟亚组相比,正常吸烟亚组、COPD吸烟亚组血清IL-6、IL-18水平均升高,而CC16水平降低;COPD吸烟亚组血清IL-6、IL-18水平高于正常吸烟亚组,而CC16水平低于正常吸烟亚组,差异均有统计学意义(P均0.05)。SI≥400亚组血清IL-6、IL-18水平高于SI400亚组,而CC16水平及MNA值均低于SI400亚组,以上差异均有统计学意义(P均0.05)。相关性分析结果显示,吸烟COPD稳定期患者的SI与血清IL-6、IL-18水平呈正相关(r分别为0.443、0.338,P均0.01),与CC16水平呈负相关(r=-0.423,P0.01);SI与MNA值呈负相关(r=-0.304,P0.05);MNA值与血清IL-6、IL-18水平均呈负相关(r分别为-0.485、-0.291,P均0.05),而与CC16水平无相关性(r=0.111,P=0.289)。结论吸烟可致COPD稳定期患者血清IL-6、IL-18水平升高、CC16水平降低,能增加COPD患者发生营养不良的风险,且与吸烟量有正相关关系。
[Abstract]:Objective to investigate the effect of smoking on the level and nutritional status of IL-18 Clara cell secretory protein CC16 in patients with chronic obstructive pulmonary disease (COPD) at stable stage. Methods the history data of 200 patients with stable COPD and 100 healthy persons (control group) were collected, and the results of mini-nutrition evaluation were collected, and lung function tests were performed on all subjects. The serum levels of IL-6 and IL-18 CC16 were measured by enzyme linked immunosorbent assay (Elisa). According to the smoking history of the subjects, smokers in the COPD group were selected as the COPD smoking subgroup, while the smokers in the control group as the normal smoking subgroup and the non-smokers as the normal non-smoking subgroup. According to smoking index (SI), COPD smoking subgroup was further divided into SI400 subgroup and SI 鈮，

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