发作期哮喘患者hs-CRP、外周血EOS的变化及与肺功能的关系

发布时间：2018-04-28 02:33

本文选题：哮喘 + hs-CRP　；参考：《实用医学杂志》2014年02期

【摘要】：目的:探讨发作期哮喘患者血清hs-CRP、外周血EOS的变化及与肺功能的关系。方法:88例急性发作期哮喘患者根据病情严重程度分为轻、中、重及危重度4组,比较患者血清hs-CRP、EO#和EO%、肺功能的变化及其相关性。结果:发作期哮喘患者病情越重,血清hs-CRP、外周血EO#及EO%水平越高(P10.05);FEV1%pred、FEV1/FVC、PEF%pred、MEF50%pred及MEF25%pred随着病情的加重而逐渐下降(P10.05);各指标在不同病情程度间的差异均有统计学意义(P0.05)。Hs-CRP与EO#正相关,与MEF50%pred、MEF25%pred负相关(P0.05)。结论 :发作期哮喘患者hs-CRP、EOS水平及肺功能检查结果与病情严重程度呈良好相关性,可作为评估哮喘病情变化的有效指标;发作期哮喘患者即使大气道功能正常,仍可能存在小气道病变,因此,在条件允许的情况下,有必要复查肺功能以监测哮喘病情变化。
[Abstract]:Objective: to investigate the changes of serum hs-CRP, peripheral blood EOS and pulmonary function in asthmatic patients. Methods 88 patients with acute asthma were divided into 4 groups according to the severity of the disease. The serum levels of hs-CRPU EO # and EO were compared, and the changes of pulmonary function and their correlation were compared. Results: the more serious asthma patients were, the higher the levels of serum hs-CRP, peripheral blood EO# and EO% were. The higher the levels of FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / FEV1 / PEFpred / PEFpred / MEF50pred and MEF25%pred gradually decreased with the exacerbation of the disease, the higher the serum hs-CRP, the higher the levels of EO# and EO% in peripheral blood. There was a negative correlation between MEF50 and MEF25pred. Conclusion: the level of hs-CRPU EOS and the results of pulmonary function examination have good correlation with the severity of asthma, and can be used as an effective index to evaluate the changes of asthma, even if the atmospheric tract function is normal in asthmatic patients. Small airway lesions may still exist, so it is necessary to review lung function to monitor changes in asthma, if conditions permit.
【作者单位】：暨南大学第二临床医学院;
【基金】：国家自然科学基金资助项目(编号:81270074/H0107)
【分类号】：R562.25

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