肺结核和肺外结核药物敏感分析

发布时间：2018-04-28 18:15

本文选题：肺结核 + 肺外结核　；参考：《中国老年学杂志》2017年23期

【摘要】：目的探讨遵义地区肺结核及肺外结核发病特征及耐药程度。方法收集遵义地区连续时间段内肺内及肺外结核患者标本分离的结核分支杆菌(MTB),进行抗结核药物敏感性检测,对人口学、临床特征、药敏结果进行比较。结果收集MTB 84株,其中9株(10.7%)分离自肺外结核病患者。通过比较人口学和临床特征,结果显示肺结核患者和肺外结核患者在年龄、性别、治疗类型及耐药类型的分布上无显著差异(P0.05)。肺结核及肺外结核病例中复治患者总耐药率和耐多药率均显著高于初治患者(均P0.05)。结论遵义地区MTB耐药较其他地区严重,应广泛开展培养及药物敏感检测,为制定准确的治疗方案提供参考,减少耐药的传播。
[Abstract]:Objective to investigate the incidence and drug resistance of pulmonary tuberculosis and extrapulmonary tuberculosis in Zunyi area. Methods Mycobacterium tuberculosis was collected from the samples of pulmonary and extrapulmonary tuberculosis patients in Zunyi area during the continuous period, and the sensitivity of anti-tuberculosis drugs was detected. The demographic, clinical characteristics and drug sensitivity results were compared. Results 84 strains of MTB were collected, 9 of them were isolated from patients with extrapulmonary tuberculosis. By comparing demographic and clinical characteristics, the results showed that there was no significant difference in age, sex, treatment type and drug resistance between pulmonary tuberculosis patients and extrapulmonary tuberculosis patients. The rates of total drug resistance and multidrug resistance in patients with pulmonary tuberculosis and extrapulmonary tuberculosis were significantly higher than those in patients with primary treatment (all P 0.05). Conclusion MTB resistance in Zunyi area is more serious than that in other areas. Culture and drug sensitivity detection should be widely carried out in order to provide reference for the formulation of accurate treatment plan and reduce the spread of drug resistance.
【作者单位】：遵义医学院附属医院;遵义医学院珠海校区;
【基金】：贵州省科学技术基金项目(No.黔科合J字[2012]2354号,黔科合J字LKZ[2010]35号)
【分类号】：R521

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