白三烯D4与乙酰甲胆碱作为支气管激发剂安全性的探讨

发布时间：2018-04-29 03:20

本文选题：乙酰甲胆碱 + D　；参考：《中国实用内科杂志》2014年S1期

【摘要】：目的比较白三烯D4作为支气管激发剂与乙酰甲胆碱在激发过程中致患者咳嗽、胸闷、气促等副反应的发生率,及恢复速率。方法 73例哮喘患者分别进行LTD4和乙酰甲胆碱支气管激发试验,比较激发剂致患者肺功能下降20%时引起咳嗽、胸闷和气促等不适症状视觉近似评分(VAS)。激发剂进行激发试验后,患者肺功能恢复正常时患者不适症状缓解情况。结果乙酰甲胆碱激发试验导致患者FEV1下降20%时VAS评分为6.0(3.0),较LTD4所致VAS评分4.0(2.0)增高明显,具有统计学意义(P0.05)。终止激发吸入万托林缓解症状,肺功能FEV1恢复到80%时,MCh引起的患者不适症状VAS评分为2.0(2.0)分,而LTD4引起的VAS评分为0.0(1.0)分,具有统计学差异(P0.05)。结论 LTD4作为支气管激发剂较乙酰甲胆碱导致患者咳嗽、胸闷、气促等症状少,且患者主观不适症状轻微,吸入万托林后白三烯导致的不适症状可在5 min内迅速缓解,而乙酰甲胆碱导致的不适症状仍存在。
[Abstract]:Objective to compare the incidence and recovery rate of the side effects of the leukotriene D4 as a bronchial activator and methacholine during the stimulation of the patient's cough, chest tightness and breath. Methods 73 patients with asthma were tested by LTD4 and methacholine bronchial provocation test, and the cough and chest tightness caused by a 20% decrease in the pulmonary function caused by the activator were compared. The visual approximate score (VAS) of the symptoms of discomfort (VAS). After the activator was tested, the patient's discomfort symptoms were relieved when the lung function was restored to normal. Results the VAS score was 6 (3) and 4 (2) was higher than that of LTD4 caused by the acetylcholine stimulation test, and was statistically significant (P0.05). The symptoms were relieved by inhalation of FEV1, and when the lung function was recovered to 80%, the VAS score of the patients with MCh was 2 (2), while the VAS score caused by LTD4 was 0 (1), with statistical difference (P0.05). Conclusion LTD4 is less than methacholine in the patients with cough, chest tightness, and shortness of breath. Mild symptoms were observed, and the symptoms of leukotriene induced by inhalation of van Lin were relieved rapidly within 5 min, while methacholine induced discomfort still existed.

【作者单位】：广州医科大学附属第一医院广州呼吸疾病研究所呼吸疾病国家重点实验室呼吸疾病国家临床医学研究中心;
【分类号】：R562.2

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