血浆可溶性血管内皮生长因子受体1在重症肺炎患者中的诊断与预测价值

发布时间：2018-05-07 00:39

  本文选题：血浆可溶性血管内皮生长因子受体 + 重症肺炎　； 参考：《郑州大学学报(医学版)》2017年01期

【摘要】：目的:探讨血浆可溶性血管内皮生长因子受体1(s FLT-1)在重症肺炎患者中的变化及预测价值。方法:选取2013年10月至2016年4月入住郑州大学附属郑州中心医院呼吸重症医学科的重症肺炎患者60例(A组)、重症肺炎合并感染性休克患者60例(B组)、重症肺炎合并MODS患者60例(C组),选取同期入住呼吸内科的社区获得性肺炎患者60例作为对照组(D组)。比较各组患者入院第1、3、7天以及存活组(n=96)和死亡组(n=84)s FLT-1水平变化,分析血浆s FLT-1在重症肺炎中的预测价值及与APACHEⅡ评分的相关性。结果:4组患者PCT和APACHEⅡ评分比较,差异有统计学意义(P均0.05)。A、B、C 3组患者血浆s FLT-1水平比较,差异有统计学意义,且A、B、C 3组第7天均低于第1天(P均0.05)。重症肺炎死亡组s FLT-1水平高于存活组(P0.001)。重症肺炎患者s FLT-1水平和APACHEⅡ评分有关(r=0.647,P0.001)。s FLT-1预测重症肺炎和28 d病死率的敏感度及特异度分别为77.8%、75.0%和69.7%、80.1%,AUC分别为0.787(95%CI=72.6%~84.8%,P0.001)和0.775(95%CI=70.5%~84.5%,P0.001)。结论:血浆s FLT-1水平可以预测重症肺炎和28 d病死率。
[Abstract]:Aim: to investigate the changes and predictive value of soluble vascular endothelial growth factor receptor (sVEGF) FLT 1 in patients with severe pneumonia. Methods: from October 2013 to April 2016, 60 severe pneumonia patients admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University, 60 patients with severe pneumonia complicated with septic shock, 60 patients with severe pneumonia with septic shock, and 60 patients with severe pneumonia combined with severe pneumonia were selected. 60 patients with MODS and 60 patients with community-acquired pneumonia who were admitted to respiratory medicine department were selected as control group. The changes of plasma s FLT-1 in patients with severe pneumonia and the correlation with APACHE 鈪，

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