无创呼吸机治疗慢性阻塞性肺疾病合并呼吸衰竭的疗效及对肺功能和血清炎症因子水平的影响

发布时间：2018-05-07 04:21

本文选题：无创呼吸机 + 慢性阻塞性肺疾病　；参考：《中国老年学杂志》2017年17期

【摘要】：目的探讨无创呼吸机(NIPPV)治疗慢性阻塞性肺疾病(COPD)合并呼吸衰竭的疗效及对肺功能和血清炎症因子的影响。方法126例COPD合并呼吸衰竭患者,按随机数字表法分为对照组和治疗组各63例。两组均接受常规治疗,包括抗感染、平喘、化痰、补液和对症支持,治疗组在常规治疗基础上给予NIPPV治疗。检测治疗14 d的肺功能和外周血炎症因子。结果两组治疗前各项肺功能和血清C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子(TNF)-α和白细胞介素(IL)-17水平无明显差异(P0.05),治疗后与对照组比,治疗组的肺功能用力肺活量(Fvc)、第1秒用力呼气容积(FEV1)、FEV1/FVC、每分钟最大通气(MVV),均改善明显,血清CRP、PCT、TNF-α和IL-17水平明显降低(P0.001)。结论NIPPV可明显改善COPD合并呼吸衰竭肺功能,并降低炎症反应。
[Abstract]:Objective to investigate the effect of noninvasive ventilator (NIPPVV) in the treatment of chronic obstructive pulmonary disease (COPD) with respiratory failure and its effects on pulmonary function and serum inflammatory factors. Methods 126 patients with COPD complicated with respiratory failure were randomly divided into control group (n = 63) and treatment group (n = 63). Both groups received routine treatment, including anti-infection, asthma, phlegm, fluid resuscitation and symptomatic support. The treatment group was treated with NIPPV on the basis of routine treatment. Pulmonary function and peripheral blood inflammatory factors were measured after 14 days of treatment. Results there were no significant differences in lung function, serum C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor TNF- 伪 (TNF- 伪) and interleukin (IL) -17 levels between the two groups before treatment (P 0.05), and compared with those in the control group (P < 0.05). In the treatment group, the forced vital capacity of lung function (FVC), forced expiratory volume (FEV1) and FEV1 / FVC (FEV1 / FVC) in the treatment group were significantly improved, and the serum levels of CRPPC TNF- 伪 and IL-17 decreased significantly (P 0.001). Conclusion NIPPV can significantly improve pulmonary function and reduce inflammation in COPD complicated with respiratory failure.
【作者单位】：齐齐哈尔医学院附属第二医院呼吸内一科;
【分类号】：R563

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