不同剂量rt-PA治疗急性肺栓塞的临床分析

发布时间：2018-05-12 11:55

本文选题：rt-PA + 剂量　；参考：《人人健康》2017年02期

【摘要】：目的:观察应用不同剂量rt-PA治疗急性肺栓塞的临床疗效。方法:选取我院2014年3月~2016年5月期间收治的92例急性肺栓塞患者作为研究对象,将其随机分为观察组(低剂量)和对照组(高剂量)各46例,比较两组患者的治疗恢复情况。结果:两组患者的治疗有效率(69.5%vs.73.9%)对比相仿(P0.05)。两组患者的PO2、PCO2、P(A-a)O2以及D-二聚体等各项血气指标较于治疗前明显改善(P0.05),两组对比无统计学意义(P0.05)。观察组患者治疗后的出血发生率(8.7%32.6%)明显高于对照组,但是其二次栓塞发生率(13.0%0)明显低于对照组,对比差异具有统计学意义(P0.05)。结论:在急性肺栓塞的临床治疗当中,应用t-PA作为溶栓治疗药物,合理选择药物使用剂量及用药方法,其中低剂量用药的安全性更高,在有效缓解患者临床症状的同时,有效降低出血风险。针对二次栓塞的发生风险,重点加以预防,进而保障患者的健康安全。
[Abstract]:Objective: to observe the clinical effect of different doses of rt-PA in the treatment of acute pulmonary embolism. Methods: 92 patients with acute pulmonary embolism admitted in our hospital from March 2014 to May 2016 were randomly divided into two groups: observation group (low dose) and control group (high dose). Results: the effective rate of treatment was 69.5% vs 73.9% (P 0.05). The blood gas indexes of the two groups were significantly improved compared with those before treatment, but there was no significant difference between the two groups. The incidence of bleeding after treatment in the observation group (8.72.6) was significantly higher than that in the control group, but the incidence of secondary embolism was 13.00) significantly lower than that in the control group (P 0.05). Conclusion: in the clinical treatment of acute pulmonary embolism, t-PA is used as thrombolytic therapy drug, and rational choice of dosage and method of drug use, among which the safety of low dose drug is higher, and the clinical symptoms of patients can be effectively alleviated at the same time. Effectively reduce the risk of bleeding. In view of the risk of secondary embolism, focus on prevention, and then ensure the health and safety of patients.
【作者单位】：内蒙古通辽市医院呼吸内科;
【分类号】：R563.5

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