辛伐他汀对慢性阻塞性肺病大鼠血浆及肺泡灌洗液中5-羟色胺表达的影响

发布时间：2018-05-18 06:26

本文选题：慢性阻塞性肺病 + 辛伐他汀　；参考：《健康之路》2015年11期

【摘要】：目的:观察辛伐他汀对慢性阻塞性肺病大鼠血浆及肺泡灌洗液中5-羟色胺表达的影响。方法:选用由山东医科大学实验动物中心所提供的40只雄性健康SD系大鼠作为研究对象,用烟熏方法制作为慢性阻塞性肺疾病大鼠模型。按照数字随机表方法进行平均分组:对照组、观察组分别为20只。观察组大鼠烟熏干预期间联用辛伐他汀治疗。对两组大鼠血浆、肺泡灌洗液中5-羟色胺的表达水平进行检测并对比。结果:对照组大鼠血浆、肺泡灌洗液中5-羟色胺检测水平分别为(7.9±0.5)pg/ml、(4.5±0.6)pg/ml,均明显高于观察组,组间数据对比可见显著差异,具有统计学意义(P0.05)。结论:慢性阻塞性肺病大鼠血浆以及肺泡灌洗液中5-羟色胺检测水平的高表达会诱发肺血管重构。辛伐他汀具有缓解肺血管重构,降低肺动脉压力的优势,对慢性阻塞性肺病的干预价值确切,可进一步展开基础实验,验证其临床应用价值。
[Abstract]:Aim: to observe the effect of simvastatin on serotonin expression in plasma and alveolar lavage fluid of rats with chronic obstructive pulmonary disease (COPD). Methods: forty male healthy SD rats provided by the Experimental Animal Center of Shandong Medical University were selected as the research objects and the model of chronic obstructive pulmonary disease (COPD) was made by fumigation. According to the method of digital random table, 20 rats were divided into two groups: control group (n = 20) and observation group (n = 20). Rats in the observation group were treated with simvastatin during fumigation intervention. The expression of 5-hydroxytryptamine in plasma and alveolar lavage fluid was detected and compared between the two groups. Results: the levels of serotonin in plasma and alveolar lavage fluid of the control group were 7.9 卤0.5 渭 g / ml and 4.5 卤0.6 渭 g / ml, respectively, which were significantly higher than those in the observation group, and there was significant difference between the two groups (P 0.05). Conclusion: the high expression of serotonin in plasma and alveolar lavage fluid may induce pulmonary vascular remodeling in chronic obstructive pulmonary disease (COPD) rats. Simvastatin has the advantages of relieving pulmonary vascular remodeling and reducing pulmonary artery pressure. The intervention value of simvastatin in chronic obstructive pulmonary disease (COPD) is definite.
【作者单位】：山东省淄博市淄川中医院;
【分类号】：R563.9

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