自噬在肺部炎症性疾病中的研究新进展

发布时间：2018-05-18 06:47

  本文选题：自噬 + 肺部炎症性疾病　； 参考：《重庆医科大学学报》2017年01期

【摘要】：自噬(autophagy)是细胞生物的一种基本特征,具有独特的调控通路,它可以选择性地降解特定的蛋白质、细胞器以及入侵的细菌。一般认为在病理生理状态下,自噬是一种细胞的保护性反应。近期研究发现在某些代谢性疾病、神经退行性病变、感染及免疫等疾病中自噬却发挥不同作用,在某些疾病中,抑制自噬会导致疾病加重,而某些疾病则反之,自噬的激活会导致疾病的发生发展。那么自噬在肺部炎症疾病中有着什么样的作用呢?本文就自噬在肺部炎症性疾病中的研究新进展作一综述。
[Abstract]:Autophagyis is a basic feature of cellular biology and has a unique regulatory pathway that selectively degrades specific proteins organelles and invasive bacteria. Autophagy is generally considered to be a cellular protective response in pathophysiological conditions. Recent studies have found that autophagy plays a different role in some metabolic diseases, neurodegenerative diseases, infections and immune diseases. In some diseases, inhibition of autophagy can lead to the exacerbation of the disease, while in some diseases the opposite is true. Autophagy activation can lead to the development of the disease. So what's the role of autophagy in lung inflammation? This article reviews the recent advances in the study of autophagy in pulmonary inflammatory diseases.
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本文编号：1904846