莫西沙星联合卡介菌多糖核酸对老年社区获得性肺炎患者炎性因子及免疫功能的影响

发布时间：2018-05-23 06:29

本文选题：莫西沙星 + 卡介菌多糖核酸　；参考：《中国老年学杂志》2017年16期

【摘要】：目的探讨莫西沙星联合卡介菌多糖核酸对老年社区获得性肺炎(CAP)患者炎性因子水平及免疫功能的影响。方法选取2016年1~12月收治的老年CAP患者80例,随机分为观察组和对照组,对照组给予莫西沙星常规治疗,观察组给予莫西沙星联合卡介菌多糖核酸治疗,分析治疗后两组血清样本中炎性因子[白细胞介素(IL)-2、-6、-8、-12]、促炎因子[肿瘤坏死因子(TNF)-α、干扰素(IFN)-γ及高敏C-反应蛋白(hsCRP)]和免疫球蛋白(Ig)G、IgA、IgM等水平,评价其治疗效果及对免疫功能的影响。结果两组总有效率差异无统计学意义(P=0.103),愈显率差异有统计学意义(P=0021)。治疗后观察组IL-6、12及hs-CRP水平极显著低于对照组(P0.01);同时IgG、IgM和IgA含量极显著高于对照组(P0.01),IFN-γ水平显著低于对照组(P0.05),IL-2、8及TNF-α水平无显著差异(P0.05)。结论莫西沙星联合卡介菌多糖核酸治疗老年CAP能有效降低血清炎性因子水平,显著改善患者免疫功能和预后。
[Abstract]:Objective to investigate the effects of moxifloxacin combined with BCG polysaccharide nucleic acid on the level of inflammatory factors and immune function in elderly patients with community acquired pneumonia (CAP). Methods 80 elderly patients with CAP in 2016 1~12 month were randomly divided into the observation group and the control group. The control group was given moxifloxacin, and the observation group was given moxifloxacin. BCG polysaccharide nucleic acid treatment, analysis of the inflammatory factors in two groups of serum samples [interleukin (IL) -2, -6, -8, -12], pro-inflammatory factors [tumor necrosis factor (TNF) - alpha, interferon (IFN) - gamma and high sensitive C- reactive protein (hsCRP)] and immunoglobulin (Ig) G, IgA, and other levels, evaluate the therapeutic effect and influence on the immune function. Results two The total effective difference was not statistically significant (P=0.103), and the difference in the rate of recovery was statistically significant (P=0021). The level of IL-6,12 and hs-CRP in the observation group was significantly lower than that of the control group (P0.01), while IgG, IgM and IgA content was significantly higher than that of the control group (P0.01), and IFN- gamma level was significantly lower than the control group (P0.05), and there was no significant difference between the IL-2,8 and the level of IgA. 0.05) conclusion moxifloxacin combined with BCG polysaccharide nucleic acid in the treatment of elderly CAP can effectively reduce serum inflammatory factors and significantly improve the immune function and prognosis of patients.
【作者单位】：哈尔滨市二四二医院;
【分类号】：R563.1

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