老年慢性阻塞性肺疾病-抑郁共病大鼠模型的建立及评价

发布时间：2018-05-27 12:42

本文选题：慢性阻塞性肺疾病 + 抑郁　；参考：《中国老年学杂志》2017年19期

【摘要】：目的建立老年慢性阻塞性肺疾病(COPD)和抑郁共病的大鼠模型,对该模型进行评价。方法通过烟熏复合慢性轻度不可预见性应激(CUMS)结合孤养建立老年COPD和抑郁共病的大鼠模型,从大鼠体征变化、肺组织病理学、大鼠肺功能、Open-field实验及糖水消耗实验等方面对模型进行评价。结果与对照组相比,老年COPD和抑郁共病模型组大鼠进食量、进水量减少,体重下降;肺组织中炎性细胞增多,肺泡壁增厚;肺功能相关指标明显下降(P0.01,P0.05);运动得分及糖水消耗明显下降(P0.05)。结论利用烟熏复合CUMS结合孤养可成功建立老年COPD和抑郁共病的大鼠模型。
[Abstract]:Objective to establish and evaluate the rat model of chronic obstructive pulmonary disease (COPD) and depression. Methods the rat model of senile COPD and depression was established by smoking combined with chronic unpredictable chronic stress (CUMS) combined with solitary care. The changes of physical signs and lung histopathology were analyzed. The pulmonary function of rats was evaluated by Open-field test and sugar water consumption test. Results compared with the control group, the rats in the aged COPD and depression co-disease model group had decreased intake, water intake and body weight, the inflammatory cells in the lung tissue were increased, and the alveolar wall was thickened. The relative indexes of lung function decreased significantly (P 0.01), and the scores of exercise and the consumption of sugar water decreased significantly (P 0.05). Conclusion smoking combined with CUMS combined with solitary care can successfully establish the rat model of COPD and depression.
【作者单位】：杭州市红十字会医院;杭州市第一人民医院;
【基金】：浙江省自然科学基金青年项目(No.LQ12H27005)
【分类号】：R-332;R563.9;R749.4

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