白三烯D4支气管激发试验预测哮喘患者上、下气道嗜酸粒细胞炎症的探讨

发布时间：2018-05-28 11:12

本文选题：支气管激发试验 + D　；参考：《中国实用内科杂志》2014年S1期

【摘要】：目的比较白三烯D4(LTD4)气道反应性不同的支气管哮喘患者(简称哮喘)上、下气道嗜酸粒细胞炎症和生活质量的差异。方法对94例乙酰甲胆碱支气管激发试验阳性,但LTD4支气管激发试验反应不同的哮喘患者(73例LTD4支气管激发试验阳性,21例LTD4支气管激发试验阴性)进行诱导痰和鼻灌洗的检测,分析各组数据的分布特点以及与AQLQ哮喘生活质量评分的相关关系。结果 LTD4支气管激发试验阴性患者诱导痰嗜酸粒细胞比例为25.50(32.41)%较阳性组(15.75(18.25)%)增高明显,阴性组患者鼻嗜酸粒细胞比例为56.25(69.98)%较阳性组(33.33(61.69)%)增高,但均未达到统计学意义(P0.05)。LTD4阳性组患者AQLQ评分为4.81(1.67)与阴性组4.63(2.06)比较无统计学差异(P0.05)。结论乙酰甲胆碱气管反应性高,但LTD4气管反应性低的哮喘患者上、下气道嗜酸粒细胞炎症明显增高,但其生活质量与阳性患者比较无明显下降。
[Abstract]:Objective to compare the difference of eosinophils inflammation and quality of life (QOL) in asthmatic patients with different airway reactivity of leukotriene D _ 4 (LTD _ 4). Methods Induction sputum and nasal lavage were detected in 94 asthmatic patients who were positive for methacholine bronchial provocation test but 73 asthmatic patients with different LTD4 bronchial provocation test and 21 patients with negative LTD4 bronchial provocation test. To analyze the distribution of data in each group and its correlation with AQLQ Asthma quality of Life (QOL) score. Results the percentage of induced sputum eosinophils in patients with negative LTD4 bronchial provocation test was 25.50 ~ 32.41% higher than that in positive group (15.75 ~ 18.25%). The percentage of eosinophil in nasal eosinophil in negative group was 56.25 ~ 69.98% higher than that in positive group (33.33 ~ 61.69%). However, there was no significant difference in the AQLQ score between the patients with positive P0.05n.LTD4 and the negative patients (4.81n1.67) and the negative group (4.63卤 2.06). There was no significant difference between the two groups (P 0.05). Conclusion the eosinophils inflammation in the lower airway of the asthmatic patients with high tracheal reactivity of methacholine but low LTD4 trachea reactivity was significantly increased, but the quality of life was not significantly decreased compared with the positive patients.
【作者单位】：广州医科大学附属第一医院广州呼吸疾病研究所(呼吸疾病国家重点实验室呼吸疾病国家临床研究中心);
【分类号】：R562.25

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