自身免疫性肺泡蛋白沉积症血清脂代谢特点

发布时间：2018-05-30 10:41

本文选题：肺泡蛋白沉积症 + 脂代谢　；参考：《中国医学科学院学报》2014年06期

【摘要】：目的探讨血脂在自身免疫性肺泡蛋白沉积症(APAP)诊断与监测中的意义。方法连续收集APAP患者血清脂代谢资料,分析32例非糖尿病APAP患者及100例健康体检者血脂水平。用ELISA法测定APAP患者血清抗粒细胞巨噬细胞集落刺激因子(GM-CSF)抗体水平。分析血脂与乳酸脱氢酶、癌胚抗原、抗GM-CSF抗体、肺功能及血气指标的相关性。结果 APAP组血清总胆固醇及低密度脂蛋白-胆固醇水平分别为(5.54±0.99)及(3.73±0.83)mmol/L,显著高于健康对照组的(5.05±0.97)及(3.17±0.89)mmol/L(P均0.05);高密度脂蛋白-胆固醇显著低于健康对照组[(1.10±0.18)比1.22(1.05-1.41)mmol/L,P均0.05]。APAP组的低密度脂蛋白/高密度脂蛋白及总胆固醇/高密度脂蛋白比值分别为3.47±0.90及5.14±1.12,显著高于健康对照组的2.63±0.87及4.18±1.12(P均0.05)。APAP组的甘油三酯水平与健康对照组的差异无统计学意义(P0.05)。高密度脂蛋白-胆固醇与肺泡动脉氧分压差呈负相关(r=-0.436,P0.05),与动脉血氧饱和度呈正相关(r=0.459,P0.05)。血脂指标与抗GM-CSF抗体无线性相关关系(P均0.05)。结论APAP患者存在血脂代谢异常,血脂异常与疾病严重程度有一定相关性,在APAP患者的评估与治疗过程中需关注血脂异常。
[Abstract]:Objective to investigate the significance of serum lipids in the diagnosis and monitoring of autoimmune pulmonary alveolar proteinosis (APAP). Methods Serum lipid metabolism data of APAP patients were collected and blood lipid levels were analyzed in 32 patients with non diabetic APAP and 100 healthy controls. Serum anti-granulocyte macrophage colony stimulating factor (GM-CSF) antibody levels in patients with APAP were measured by ELISA method. To analyze the correlation between blood lipid and lactate dehydrogenase, carcinoembryonic antigen, anti GM-CSF antibody, pulmonary function and blood gas index. Results the levels of serum total cholesterol and low density lipoprotein cholesterol in APAP group were 5.54 卤0.99) and 3.73 卤0.83 mmol / L, respectively, which were significantly higher than those in healthy control group (5.05 卤0.97) and 3.17 卤0.89)mmol/L(P, respectively, and high density lipoprotein cholesterol was significantly lower than that in healthy control group (1.10 卤0.18) vs 1.221.05-1.41mmolL / L, respectively. The ratio of low density lipoprotein / high density lipoprotein and total cholesterol / high density lipoprotein were 3.47 卤0.90 and 5.14 卤1.12, respectively, which were significantly higher than those of the healthy control group (2.63 卤0.87 and 4.18 卤1.12p). There was no significant difference in triglyceride levels between the 0.05).APAP group and the healthy control group (P 0.05). There was a negative correlation between high density lipoprotein cholesterol and alveolar arterial oxygen partial pressure difference (P0. 05) and a positive correlation between HDL-C and arterial oxygen saturation (P 0. 05). The correlation between serum lipids and anti-GM-CSF antibody was 0. 05% (P < 0. 05). Conclusion there is abnormal metabolism of blood lipids in patients with APAP, and there is a certain correlation between dyslipidemia and severity of the disease. Attention should be paid to dyslipidemia in the course of evaluation and treatment of patients with APAP.
【作者单位】：中国医学科学院北京协和医学院北京协和医院呼吸科;
【分类号】：R563.9

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