SCOPD合并SAP患者心肺有关标志物及炎症因子观察

发布时间：2018-05-30 11:14

本文选题：慢性阻塞性肺疾病稳定期 + 稳定性心绞痛　；参考：《中国中西医结合杂志》2017年09期

【摘要】：目的研究稳定期慢性阻塞性肺病(SCOPD)合并稳定性心绞痛(SAP)患者血清心肺有关标志物特征与关联。方法选择SCOPD合并SAP患者242例(合并组)、SCOPD患者60例(SCOPD组)、健康体检者30名(健康组)。采集受试者一般资料,采空腹静脉血检测N端脑钠肽前体(NT-proBNP)、c Tn I、Clara细胞分泌蛋白(CC16)、表面活性蛋白-D(SP-D)、白介素-1β(IL-1β)、白介素-10(IL-10)及C反应蛋白(CRP),并行肺功能检测,比较上述指标的差异,并在SCOPD组及合并组患者中进行亚组分析,对合并组上述标志物进行线性相关分析。结果与健康组比较,两个患者组NT-pro-BNP、c Tn I、SP-D、IL-1β及CRP升高(P0.05),SCOPD组低于合并组(P0.05);而CC16和IL-10降低(P0.05),合并组低于SCOPD组(P0.05)。亚组分析显示大部分指标亦随病情加重而波动。合并组血清NT-pro-BNP、c Tn I与CC16呈负相关(P0.01),与SP-D呈正相关(P0.01);心肺有关标志物与部分炎症标志物相关(P0.01)。结论 SCOPD合并SAP患者较SCOPD患者心肺损伤严重,炎症可能是其重要机制,且心肺有关标志物之间具有相关性。
[Abstract]:Objective to study the characteristics and correlation of serum cardiopulmonary markers in patients with stable chronic obstructive pulmonary disease (SCOPD) complicated with stable angina pectoris (SAP). Methods two hundred and twenty two patients with SCOPD combined with SAP (60 patients with SCOPD and 30 healthy controls) were selected. The general data of the subjects were collected and the fasting venous blood samples were collected to detect the secretory protein CC16 of NT-proBNPP, the surface-active protein DnSP-DX, the interleukin-1 尾 -tir IL-1 尾, interleukin-10 (IL-10) and C-reactive protein (C-reactive protein) CRP, and to compare the above indexes. Subgroup analysis was carried out in SCOPD group and combined group, and linear correlation analysis was carried out on these markers in the combined group. Results compared with the healthy control group, the levels of NT-pro-BNPC Tn-Tn-Tn-Tn-Tn-DP-DN- 尾 and CRP in SCOPD group were significantly higher than those in the combined group (P 0.05), while the levels of CC16 and IL-10 were lower than that in the SCOPD group (P 0.05), and the levels of CC16 and IL-10 in the combined group were lower than those in the SCOPD group (P 0.05). Subgroup analysis showed that most of the indexes fluctuated with the aggravation of the disease. In the combined group, the serum NT-pro-BNPC TnI was negatively correlated with CC16 and positively correlated with SP-D (P0.01A), and the related markers of heart and lung were correlated with some inflammatory markers (P0.01). Conclusion the cardiopulmonary injury in SCOPD patients with SAP is more serious than that in SCOPD patients. Inflammation may be an important mechanism, and there is a correlation between cardiopulmonary markers.
【作者单位】：河北医科大学研究生学院;河北医科大学附属以岭医院心血管内科国家中医药管理局中医络病学重点学科;石家庄以岭药业股份有限公司络病研究与创新中药国家重点实验室;河北以岭医药研究院国家中医药管理局重点研究室(心脑血管络病)河北省络病重点实验室;
【基金】：国家重点基础研究发展计划(973计划)资助项目(No.2012CB518606)
【分类号】：R541.4;R563.9

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